The Molecular biology of neurological disease
著者
書誌事項
The Molecular biology of neurological disease
（Butterworths international medical reviews, Neurology ; 9）
Butterworths, 1988
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注記
Includes bibliographies and index
内容説明・目次
内容説明
International experts review advances in the understanding of the molecular mechanisms of both normal and abnormal neurological functions and their immediate and future applications in clinical neurology. The 'new genetics' also has many applications in other neurological problems, including oncology, urology, development, growth and differentiation and chemical neurotransmission. Clinicians need to understand the basis of molecular genetics - techniques such as recombiant DNA technology and genetic linkage studies. These have immediate clinical relevance, for example in the development of therapeutic products, in the presymptomatic and prenatal detection of genes carriers, so important in genetic counselling and in the understanding of disease pathophysiology.
目次
- Molecular genetics and neurological disease - basic principles and methods
- genes expressed in the brain - evolutionary and developmental considerations
- in-situ hybridization - visualizing brain messenger RNA
- molecular biology of chemical neurotransmissions
- proteins which regulate the development of the nervous system
- gene expression in skeletal muscle
- host and viral genetic factors which influence viral neurotropism
- neuro-oncogenesis - recessive genes, activated oncogenes and chromosome abnormalities in the development of neuro-ectodermal cancers
- transigenic mice and neurological disease
- molecular genetics of Joseph disease
- Huntingdon's disease
- molecular genetics and muscular dystrophy
- mitochondrial genes and neurological disease
- molecular basis of retinoblastoma
- detection of viral genes in neurological disease
- immunogenetics - genetic polymorphism and susceptibility to neurological disease
- a neurological gene map.
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