Inhibitors of ribonucleoside diphosphate reductase activity
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Bibliographic Information
Inhibitors of ribonucleoside diphosphate reductase activity
(International encyclopedia of pharmacology and therapeutics)
Pergamon Press, 1989
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Includes bibliographies and index
Description and Table of Contents
Description
The replication of DNA prior to cell division requires the process of deoxyribonucleoside triphosphate substrates for DNA polymerase. The enzyme which catalyzes the formation of deoxyribonucleotide is referred to as ribonucleotide reductase. The purpose of this volume is to review studies dealing with the ribonucleotide reductase in prokaryotic and eukaryotic cells and factors which may be involved in the control of deoxyribonucleotide formation in mammalian cells, including the use of inhibitors of ribonucleotide reductase in relation to anti-tumor chemotherapy.
Table of Contents
- Role of ribonucleotide reductase in cell division, J. G. Cory. Nature and properties of the bacterial ribonucleotide reductases, H. P. C. Hogenkamp & S. C. McF
- rlan. Nature and properties of mammalian ribonucleoside diphosphate reductase, L. M. Nutter & Y. Cheng.
- Progress on the chemical mechanism of the ribonucleotide reductases, G. W. Ashley & J. Stubbe
- Altered mammalian ribonucleoside diphosphate reductase from mutant cell lines, J. A. Wright. Changes in deoxynucleoside triphosphate pools induced by inhibitors and modulators of ribonucleotide reductase, R. M. Fox. The role of ribonucleotide reductase in regulation of the deoxyribonucleoside triphosphate pool composition, R. C. Jackson. Is the mammalian ribonucleotide reductase really like Escherichia coli's ribonucleotide reductase? J. F. Whitfield & T. Youdal
- . The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole, and pyrazoloimidazole (IMPY), E. C. Moore & R. B. Hur
- bert. Inhibition of ribonucleotide reductase by alpha-(N)-heterocyclic carboxyaldehyde thiosemicarbazones, E. C. Moore & A. C. Sar
- orelli. The inhibition of nucleoside diphosphate reductase by hydroxy-benzohydroxamic acid derivatives, H. L. Elford & B. van't
- iet. Ribonucleotide reductases encoded by herpes viruses: inhibitors and chemotherapeutic considerations, T. Spector. Combination chemotherapy directed at the components of nucleoside diphosphate reductase, J. G. Cory & P. Chiba.
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