Peptides of poisonous Amanita mushrooms
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書誌事項
Peptides of poisonous Amanita mushrooms
（Springer series in molecular biology）
Springer-Verlag, c1986
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注記
Bibliography: p. [213]-247
Includes index
内容説明・目次
内容説明
During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known ofthe chemical constitution of biological systems, the manner in which information was transmitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramatically different. We have an almost bewildering variety of information detailing many different aspects oflife at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for replicating, distributing and modifying biological information. We have learned a great deal about the chemical and physical nature of the macro- molecular nucleic acids and proteins, and the manner in which carbohydrates, lipids and smaller molecules work together to provide the molecular setting of living systems. It might be said that these few decades have replaced a near vacuum of informa- tion with a very large surplus. It is in the context of this flood of information that this series of monographs on molecular biology has been organized.
The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field. This will enable the reader to get a sense of historical perspective- what is known about the field today - and a description of the frontiers of research where our knowledge is increasing steadily.
目次
Mushrooms Causing Death in Rare Cases.- Deadly Poisonous Amanita Mushrooms and Their Constituents.- Toadstools Accumulating Amatoxins.- Poisoning by Amatoxins.- Two Centuries of Amanita Research.- Recognition, Isolation, and Characterization of the Peptide Toxins.- Recognition of Toxic Components.- Chromatographic Procedures.- Paper Chromatography.- Thin-Layer Chromatography.- Visualization.- Color Reaction on Newsprint.- Liquid Chromatography.- Quantification of Amatoxins and Phallotoxins.- Quantitative Chromatography.- High-Performance Liquid Chromatography.- Radioimmunoassay.- Inhibition of RNA Polymerase.- Phallotoxins and Actin.- Quantities of Toxic Cyclopeptides in Various Mushrooms.- Isolation and Characterization of the Cyclopeptides.- Isolation.- Chemical Properties.- Physical Properties.- Mass Spectroscopy.- Ultraviolet Spectroscopy.- Fluorescence and Phosphorescence.- Circular Dichroism (CD) and Optical-Rotatory Dispersion (ORD).- Nuclear Magnetic-Resonance (NMR) Spectroscopy.- Toxicological Properties.- The Chemistry of the Amatoxins, Phallotoxins and Virotoxins.- Common Features.- The Hydroxyamino Acids.- Elucidation of the Structure and Synthesis of the Non-Lactonizing Members.- Elucidation of the Structure and Synthesis of the Lactonizing Amino Acids.- Amatoxins.- Structure and Conformation.- Structure-Activity Relationships.- The 6'-Hydroxyl Group.- Molecular Shape.- The Sulfoxide Moiety.- The Side Chains.- Chemical Modifications at the 6' -Hydroxy-Indole Moiety.- Protein Conjugates of Amatoxins.- Methods of Conjugation.- Radioactively-Labelled Amatoxins.- Phallotoxins.- Structure and Conformation.- Spatial Structure of Phallotoxins.- Structure-Activity Relationships.- Molecular Shape.- The Role of the Side Chains.- Chemical Modifications.- Synthetic Analogues.- Conclusions.- Virotoxins.- Structure.- Structure-Activity Relationships.- Presumptive Derivation from Phallotoxins.- Synthetic Approaches at the Toxic Peptides.- Synthesis of Thioethers of L-Tryptophan.- Peptide Synthesis.- Cyclization.- Synthesis of Phallotoxins.- Total Synthesis of Phalloin.- The Savige-Fontana Approach.- Analogues of Amanin.- Molecular Pathology of the Amanita Peptides.- Uptake of the Toxins by the Liver.- Amatoxins.- Mechanism of Amatoxin Intoxication.- Pathological Symptoms of Intoxication.- Inhibition of RNA Synthesis.- The Amatoxin-RNA-Polymerase II Complex.- The Amatoxin-Binding Subunit.- Other Amatoxin-Binding Proteins.- The Mechanism of Polymerase Inhibition.- Susceptibility of RNA Polymer ases from Different Origin.- Amatoxins in Cell Biology.- Morphological and Biochemical Effects in Vivo.- Effect of Amatoxins on Isolated Cells.- Amatoxin-Resistant Cell Lines and Organisms.- Amanitin-Resistant Drosophila.- Amatoxins in Virus Research.- Deoxyriboviruses.- Riboviruses.- Amatoxins in Physiology.- Hormonal Induction of Protein Synthesis.- Phallotoxins and Virotoxins.- Molecular Mechanism of Toxicity.- Phenomenology of Intoxication.- Interaction of Phalloidin with Actin.- The Pathological Events, a Consequence of the Phallotoxin-Actin Interaction.- Swelling of the Liver, Vacuolization.- Secretory Processes.- Inhibition of Protein Synthesis.- Effects on Stimulatory Transmission.- Phalloidin and Motility of Cells.- Influence on Muscle Contraction.- Influence on Cytoplasmic Streaming and Motility of Non-Muscle Cells.- Fluorescent Phallotoxins as Tools in Biological Research.- Visualization of F-Actin.- Eicosanoids and Actin Fibers.- Actin Structure and Cell Transformation.- Miscellaneous Studies.- Tolerance and Protective Agents.- Tolerance.- Antagonists, Protectors.- Non-Toxic Peptides from Amanita phalloides.- Antamanide and Other Cycloamanides.- Antamanide.- Isolation and Properties.- Structure of Antamanide.- Synthesis of Antamanide and Analogues.- Metal-Ion-Complexing Properties.- Complexing Aptitude and Biological Activity.- Conformations of Antamanide and Analogues.- Structure-Activity Relationships.- Solubility.- The Mode of Action of Antamanide.- Additional Cycloamanides.- Phallolysin.- Hemolytically-Active Proteins from Mushrooms and Bacteria.- Purification and Characterization of Phallolysin.- Mechanism of Hemolytic Activity.- Toxicity.- Mechanism of Action.- Similarity of the Hemolytic Effects of Phallotoxin and Staphylococcal?-Toxin.- Retrospectives and Outlook.- References.
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