Neuropharmacology and pesticide action

著者

書誌事項

Neuropharmacology and pesticide action

edited by M.G. Ford ... [et al.]

（Ellis Horwood series in biomedicine）

VCH , Ellis Horwood, 1986

  • : us
  • : gw

タイトル別名

NEUROTOX '85

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注記

"NEUROTOX '85, published for the Pesticide Group and the Physicochemical & Biophysical Panel of the Society of Chemical Industry"--T.p. verso

"The papers presented in this volume are transcripts of the invited lectures at Neurotox '85, an international symposium held at the University of Bath , England"--Prologue

Includes bibliographies and index

内容説明・目次

内容説明

This collection of 21 articles summarizes the major advances that have occurred over the last few years in the neuropharmacology of pesticides. The articles were presented at Neurotox '85, an international symposium held at the University of Bath, England. The contributors emphasize the molecular basis of neuropharmacology and neurobiology, with examples taken from invertebrate and vertebrate nervous systems. They also stress the relationship between the chemical structure and neurotoxicity and describe the effects of neurotoxicants upon molecular and cellular components within the nervous system. Among the topics discussed are structure$activity analysis in drug design, the use of computer graphics to study drug-receptor interactions, and avermectins, a new type of pesticide.

目次

  • Excitable Membranes
  • The Biochemistry of Neuronal Membranes
  • Saxitoxin and the Voltage-Gated Sodium Channels of Excitable Tissues
  • Mechanisms of Action of Pyrethroids on Sodium and Calcium Channel Gating
  • Sensitivity of Nicotinic and Glutamatergic Synapses to Reversible and Irreversible Cholinesterase Inhibitors
  • Molecular Pharmacology
  • Chemical Properties and Structure$Activity Analysis in Drug Design
  • Application of Computer Graphics to the Study of Drug-Receptor Interactions
  • Depression of Glutamate Response by Trimethylenediamine Derivatives at the Crayfish Neuromuscular Junction
  • Molecular Pharmacology and Biophysics of Insect Muscle Tissue Studied Using Patch-Clamp Techniques
  • Pesticide Neurobiology
  • Neurotransmitter Receptors of Vertebrates and Insects as Targets for Insecticides
  • Biological Activity and Mode of Action of Avermectins
  • Insect Neurosecretory Cells_Structural and Physiological Effects Induced by Insecticides and Related Compounds
  • Pyrethroid Action and Cellular Activity in Invertebrate Neurons
  • The Effect of Pyrethroid Structure on the Interaction with the Sodium Channel in the Nerve Membrane
  • Cellular Pharmacology
  • Modulations of Transmission at Crustacean Neuromuscular Synapses
  • The Action of Pesticides on Biogenic Amine Receptors and Second Messenger Systems in Insects
  • Cellular and Molecular Actions of Neuropeptides
  • The Interaction of Insect-Selective Neurotoxins from Scorpion Venoms with Insect Neuronal Membranes
  • Synaptosomes_Systems for Studying Insect Neurochemistry
  • GABA Receptors in Parasites of Veterinary Importance
  • Insect Neuronal Cultures_A New Tool in Insect Neuropharmacology
  • Insect Acetylcholine Receptors_Biochemical and Physiological Approaches
  • Epilogue
  • Index.

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