Central D[1] dopamine receptors
著者
書誌事項
Central D[1] dopamine receptors
(Advances in experimental medicine and biology, v. 235)
Plenum Press, c1988
大学図書館所蔵 全11件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
"Based on the proceedings of the Symposium on Central D[1] Dopamine Receptors, held December 5, 1986, in New York, New York"--T.p. verso
Includes bibliographies and index
内容説明・目次
内容説明
The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems.
Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects.
目次
Dopamine-Regulated Protein Phosphorylation in the Basal Ganglia.- The D-1 Dopamine Receptor.- Biochemical Properties of D-1 and D-2 Dopamine Receptors.- Biochemical and Functional Characterization of Central Dopamine Receptors.- Dopamine D-1 and D-2 Receptor Selectivities of Agonists and Antagonists.- DARPP-32 as a Marker for D-1 Dopaminoceptive Cells in the Rat Brain: Prenatal Development and Presence in Glial Elements (Tanycytes) in the Basal Hypothalamus.- Studies on Central D-1 Receptors Role in Volume Transmission, Neuroendocrine Regulation and Release of Noradrenaline.- N-Ethoxycarbonyl-2-Ethoxy-1,2-Dihydroquinoline (EEDQ): A New Tool to Probe CNS Receptor Function.- Pharmacological and Behavioral Effects of D-1 Dopamine Antagonists.- Neurophysiological Examination of the Role of D-1 Dopamine Receptors in the Regulation of Neuronal Activity in the Basal Ganglia.- Diminished D-2 Dopamine Receptor Function and the Emergence of Repetitive Jaw Movements.- D-1 Dopamine Receptors and Arousal.
「Nielsen BookData」 より