Oncogenes : an introduction to the concept of cancer genes
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Bibliographic Information
Oncogenes : an introduction to the concept of cancer genes
Springer-Verlag, c1988
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- gw
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Includes bibliographies and index
Description and Table of Contents
- Volume
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us ISBN 9780387964232
Description
"Cancer viruses" have played a paradoxical role in the history of cancer research. Discovered in 1911 by Peyton Rous (1) at the Rockefeller Institute, they were largely ignored for several decades. Witness his eventual recognition for a Nobel Prize, but not until 1966-setting an all time record for latency, and testimony to one more advantage of longevity. In the 1950s, another Rockefeller Nobelist, Wendell Stanley, spearheaded a campaign to focus attention on viruses as etiological agents in cancer, his plat form having been the chemical characterization of the tobacco mosaic virus as a pure protein-correction, ribonucleoprotein-in 1935 (2). This doctrine was a centerpiece of the U.S. National Cancer Crusade of 1971: if human cancers were caused by viruses, the central task was to isolate them and prepare vaccines for immunization. At that point, many observers felt that perhaps too much attention was being devoted to cancer viruses. It was problematic whether viruses played an etiological role in more than a handful of human cancers.
Table of Contents
1 Introduction.- 2 Assays: Tools of the New Biology.- 3 Viruses and Oncogenes.- 4 Human T Cell Lymphotropic/Leukemia Viruses.- 5 Cellular Proto-oncogenes.- 6 Oncogenes and Human Cancers.- 7 src and Related Protein Kinases.- 8 Growth Factors and Receptors.- 9 ras Family of Oncogenes.- 10 myc and Other Nuclear Oncogenes.- 11 Additional Oncogenes.- 12 Transgenic Mice: Direct In Vivo Assay for Oncogenes.- 13 Potential Diagnostic Uses of Oncogenes.- 14 Potential Therapeutic Applications of Oncogenes.- 15 Oncogene Paradigm: Contribution to a Fundamental Understanding of Malignancy.- Appendix: Oncogenes and Related Genes.
- Volume
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gw ISBN 9783540964230
Description
This topical, handy volume is the perfect guide for physicians or scientists not specializing in the field, but wishing to understand exciting recent developments in cellular and molecular biology relevant to oncogene research. The terminology used in discussing oncogenes and their products is straightforwardly defined, and the concepts crucial to an understanding of oncogene research are clearly presented. Key topics are explored, including assay techniques used in molecular biology; methods for assessing behavior of normal genes and oncogenes; DNA and RNA tumor viruses; viruses inducing immunodeficiency; cellular proto-oncogenes and their relation to retroviral oncogenes; and possible roles of gene amplification and mutation, chromosomal translocation, and cellular growth factors in human cancer. An up-to-date survey of research on the major oncogenes and a discussion of the possibilities for future diagnostic and therapeutic applications of oncogene research are provided. The presentation is enhanced through many original illustrations, an appendix on oncogenes and related genes, and an up-to-date bibliography.
Table of Contents
Contents: Introduction.- Assays: Tools of the New Biology.- Viruses and Oncogenes.- Human T Cell Lymphotropic/Leukemia Viruses.- Cellular Proto-oncogenes.- Oncogenes and Human Cancers.- src and Related Protein Kinases.- Growth Factors and Receptors.- ras Family of Oncogenes.- myc and Other Nuclear Oncogenes.- Additional Oncogenes.- Transgenic Mice: Direct In Vivo Assay for Oncogenes.- Potential Diagnostic Uses of Oncogenes.- Potential Therapeutic Applications of Oncogenes.- Oncogene Paradigm: Contribution to a Fundamental Understanding of Malignancy.- Appendix: Oncogenes and Related Genes.- Index.
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