Human monoclonal antibodies : current techniques and future perspectives : proceedings of the first IRI International Symposium on Biotechnology: 'Monoclonal Antibodies in the Treatment of Human Disease', November 10-12, 1986, Edinburgh, UK

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Human monoclonal antibodies : current techniques and future perspectives : proceedings of the first IRI International Symposium on Biotechnology: 'Monoclonal Antibodies in the Treatment of Human Disease', November 10-12, 1986, Edinburgh, UK

edited by J. Brown

IRL Press, c1987

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Includes index

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内容説明

Comprising the proceedings of the symposium Monoclonal Antibodies in the Treatment of Human Disease, held in Edinburgh, UK, November 10-12 1986, this study presents the work of international researchers closely involved in the pursuit of a consistent technique to generate human monoclonal antibodies with potential clinical applications. Contributors discuss basic research in human monoclonal antibody production, and related industrial production and regulatory issues. Readership: immunology, pharmacology, biotechnology clinicians, researchers.

目次

  • The use of the Epstein-Barr virus for the production of human monoclonal antibody-secreting cell lines
  • Human monoclonal antibodies with potential for treating malaria
  • Production of human anti-D(Rh) antibodies by human - mouse hybridomas
  • Application of the EBV-hybridoma technique to cancer and `infectious' disease
  • The use of fusion partners in the production of human monoclonal antibodies
  • The production of hybrid monoclonal antibodies capable of targeting human cytotoxic T cells
  • Immortalization of stimulated lymphocytes by transfection with oncogenic DNA
  • Mouse to human monoclonals by protein engineering
  • Viruses as tools for generating immortalised cells--is there an alternative to EVB for human B-cells?
  • Regulatory requirements for monoclonal antibodies for use in human therapy

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