Chemical carcinogens : activation mechanisms, structural and electronic factors, and reactivity
著者
書誌事項
Chemical carcinogens : activation mechanisms, structural and electronic factors, and reactivity
（Bioactive molecules, v. 5）
Elsevier, 1988
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注記
Includes bibliographies and index
内容説明・目次
内容説明
Since 1978, annual Interdisciplinary Cancer Research Workshops have been held at the University of New Orleans. In 1987 it seemed appropriate to consider an extended publication that would mark the completion of the first decade of these meetings. This volume is the result. A number of the distinguished researchers who participated in the first ten workshops have contributed chapters summarizing their current work in the area of chemical carcinogenesis. These contributions cover a wide range of topics, are particularly up-to-date, and reflect a consistently high level of scientific investigation which will both inform and stimulate all those currently active in - or entering some area of - cancer research.
目次
1. Metabolic and Chemical Activation of Carcinogens: An Overview (Y.T. Woo et al.). 2. Reactive Metabolites of Carcinogens and Their Interactions with DNA (A. Dipple). 3. DNA Adducts In Vitro and In Vivo (K. Hemminki). 4. Carcinogenic Halogenated Aliphatic Compounds (E.K. Weisburger). 5. Chemistry, Reactivity and Carcinogenicity of Chloro Ethers (B.L. Van Duuren, S.B. Van Duuren). 6. Carcinogenicity of Ethylene and its Derivatives: Structural Considerations (H.M. Bolt). 7. Reactions of Vinyl Chloride and its Metabolites with Bases in Nucleic Acids and the Potential Biological Consequences (B. Singer et al.). 8. Computational Studies of Olefin and Epoxide Carcinogenicity (P. Politzer). 9. Irregularities of DNA Structure and Their Effects on DNA Replication (L.S. Kan, P.O.P. Ts'o). 10. Nucleic Acid Alkylation by N-Nitroso Compounds Related to Organ-Specific Carcinogenesis (W. Lijinsky). 11. Nitro-Polycyclic Aromatic Hydrocarbons: Structural Features, Genotoxicity, and Risk Evaluation (R.W. Hart et al.). 12. Methyl Bay Region Diol Epoxides: Key Intermediates in the Metabolic Activation of Carcinogenic Methylated Polynuclear Aromatic Hydrocarbons (S.S. Hecht et al.). 13. Estrogen Carcinogenicity: Hormonal, Morphologic and Chemical Interactions (J.J. Li et al.). 14. Theoretical Implications of the k e Carcinogen-Screening Test (G. Bakale). 15. A Microspectrofluorometric Study of the Cell's Multiorganelle Detoxification Complex and Intracellular Carcinogen Interactions (E. Kohen et al.). Subject Index.
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