Medical, biochemical, and chemical aspects of free radicals : proceedings of the 4th Biennial General Meeting of the Society for Free Radical Research, Kyoto, Japan, 9-13 April 1988

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書誌事項

Medical, biochemical, and chemical aspects of free radicals : proceedings of the 4th Biennial General Meeting of the Society for Free Radical Research, Kyoto, Japan, 9-13 April 1988

edited by O. Hayaishi ... [et al.]

Elsevier, 1989

  • : set
  • v. l
  • v. 2

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注記

"Contain[s] the record of the International Conference on Medical, Biochemical, and Chemical Aspects of Free Radicals which was held ... as the Fourth General Meeting of the Society for Free Radical Research"--Pref

Includes bibliographies and index

内容説明・目次

内容説明

There is now increasing evidence that free radicals play an important role in biological systems and that they are closely connected to a variety of pathological events, including cancer and aging. It is also known that biological systems are protected against free radical attack by an array of defence systems, e.g. vitamins C and E and superoxide dismutase. However, details of the generation, function and scavenging of free radicals or repair are not well understood and are often controversial. These two volumes contain almost 320 papers from the international community of experts in this field. Taken as a whole, the work provides the present state of the art of the role of free radicals from medical, biochemical and chemical viewpoints. The volumes will thus be of interest to chemists, biochemists, pharmacologists, medical scientists and clinicians, and to those working in the pharmaceutical and chemical industries.

目次

(Due limitations of space only a random selection of papers are listed below). VOLUME I. Overview. Disturbances of free radical reactions: A cause or consequence of cell injury? (T.F. Slater). Oxygen radical mediated inactivation of enzymes: Biological implication (E.R. Stadtman). Iron (8 papers): The role of iron in free radical reactions (B. Halliwell, J.M.C. Gutteridge). Role of iron in lipid peroxidation (V.M. Samokyszyn, S.D. Aust). Active Oxygen (33 papers): Reactive oxygen metabolites produced by erionite, a carcinogenic mineral fiber (N. Urano et al.). Fast protective responses in plants to oxidative drought stress (A.H. Price, G.A.F. Hendry). Dehydrogenation of alcohols by stable phenoxy radicals (A. Nishinaga et al.). Vitamin E (19 papers): Vitamin E and mitochondrial ubiquinone status in exercise training (K. Gohil et al.). Biokinetic studies of vitamin E in man (G.W. Barton et al.). Antioxidants (55 papers): Influence of antioxidant vitamins on cataract formation (L.J. Machlin). A novel active oxygen species scavenger, CV-3611 (S. Terao). Effects of oxygen tension on selenium metabolism (P. Garberg, J. Hogberg). Superoxide Dismutase (39 papers): A preliminary detection of human cancer by determining the whole blood superoxide dismutase activity (Lan Kai-Wei). Effect of SOD on lupus nephritis (T. Sato et al.). Recombinant human manganese superoxide dismutase is a potent anti-inflammatory agent (A. Nimrod et al.). VOLUME II. Assay Methods (35 papers): Spin trapping for biology and medicine (E.G. Janzen). Analysis of lipid peroxidation by HPLC (Y. Yamamoto). Ethane in the exhaled air during circulatory shock in rats (G.P. Novelli et al.). Lipid Peroxidation (14 papers): Lipid peroxidation and tissue damage (G. Poli et al.). Lipid peroxidation and inhalation toxicity by pesticide particle (M. Ando et al.). Lipid Peroxide (16 papers): Degradation of myocardial membrane phospholipids by oxygen-derived free radicals (M. Renuka Prasad et al.). A study of urinary lipid peroxides in neonates (T. Aoki, Y. Kobayashi). Prostaglandins (9 papers): Reactions catalyzed by plant lipoxygenases (J.F.G. Vliegenthart, G.A. Veldink). A cage radical mechanism for prostacyclin and thomboxane synthase (V. Ullrich, M. Hecker). Ischemia-Reperfusion (14 papers): Sources of oxygen-derived radicals in ischemia-reperfusion (J.M. McCord et al.). Pathology (58 papers): Free radicals. Erythrocyte disorders and iron decompartmentalisation (C. Rico-Evans, A. Hartley). Mixed function oxidation of glutamine synthetase: Correlation of chemical and biochemical alterations (R.L. Levine, J. Rivett). Clinical study of free radical in multiple organ failure after open heart surgery (T. Murashita et al.). Effect of protease inhibitors on production of active oxygen species in human polymorphonuclear leukocytes (K. Tamura et al.). Cancer (17 papers): The measurement of oxidative damage in humans: relation to cancer and ageing (B.N. Ames).

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