Natural products isolation : separation methods for antimicrobials, antivirals, and enzyme inhibitors
Author(s)
Bibliographic Information
Natural products isolation : separation methods for antimicrobials, antivirals, and enzyme inhibitors
（Journal of chromatography library, v. 43）
Elsevier, 1989
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Note
Includes bibliographical references and indexes
Description and Table of Contents
Description
This new book encompasses, in great detail, the most recent progress made in the isolation and separation of natural products. It covers antibiotics, marine and plant-derived substances, enzyme inhibitors and interferons. The most recent separation methodology is described. Although there is a bias toward antibiotics, it was done because this is still the largest natural products area of research. The fourteen chapters are written by experts in their respective fields. The first two chapters are largely devoted to new methodology applied to purification of a variety of compounds. They include an extensive review and new applications of counter-current chromatography and the newly emerging HPLC-photodiode array technology. Chapter 3 provides a review of affinity chromatography applied to the separation of antibiotics for the first time. Next are chapters on antimicrobials with an update on all the most recent b-lactam (after 1976) discoveries. A comprehensive review of a very important class of antiparasitic agents - the avermectins - follows. An update of isolation and purification of a variety of marine-derived compounds is next.
Table of Contents
Countercurrent Chromatography (J.B. McAlpine and J.E. Hochlowski). HPLC Detection Methods for Microbial Products from Fermentation Broth (R. Mierzwa, J.A. Marquez, M. Patel and R. Cooper). Affinity and Purification of Glycopeptide Antibiotics (R.D. Sitrin and G.F. Wasserman). Nikkomycins and Polyoxins (H.-P. Fiedler). Saframycins and Isoquinolines (T. Arai). New Cephalosporins (S. Harada). Monocyclic Beta-Lactam Antibiotics (W.L. Parker). Isolation of Carbapenems (K.E. Wilson). Avermectins and Related Compounds (T. Miller and V.P. Gullo). Bioactive Compounds from Marine Organisms and Cultivated Blue-Green Algae (J.S. Mynderse, L.W. Crandall and J.H. Cardellina II). The Interferons (S. Pestka). Enzyme Inhibitors Produced by Microorganisms (H. Umezawa). Alkaloidal Glycosidase Inhibitors from Plants (L.E. Fellows and G.W.J. Fleet). Chemical Communication and Control of Development (C.E. Smith, J.D. Orr and D.G. Lynn). Subject Index.
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