LHRH and its analogues : their use in gynaecological practice
著者
書誌事項
LHRH and its analogues : their use in gynaecological practice
Wright, 1989
注記
Includes bibliographies and index
内容説明・目次
内容説明
The isolation and characterization of the hypothalamic releasing hormone LHRH in 1971 allowed researchers to begin to investigate the complex nature of the feedback control of pituitary gonadotrophin secretion. Further research explored the use of synthetic analogues of LHRH and their effects in diverse gynaecological and female reproductive disorders. Although in many clinical conditions the ultimate role of LHRH analogues has still to be established, their value in others is clearly apparent. Safety data accruing with regard to general metabolic and biochemical parameters suggests the need for careful studies to determine recommended dosage, formulation and duration of use of these compounds. This book brings together the current research results of a group of international colleagues, many of whom have been involved in the study of LHRH and its analogues since the earliest clinical trials. The contributors have produced a detailed review of the role of LHRH compounds in gynaecological practice, which the authors hope will encourage individual readers to undertake further practice and research.
目次
- Control of gonadotrophin secretion, J.C.Marshall
- cellular actions of gonadotrophin-releasing hormone - the receptor and beyond, R.N.Clayton
- chemistry and metabolism of LHRH and its analogues, J.Sandow
- formulation of luteinizing hormone-releasing hormone analogues, B.J.A.Furr and F.G.Hutchinson
- extra-pituitary actions of LHRH analogues and LHRH-like peptides, H.M.Fraser and K.A.Eidne
- diagnostic uses of LHRH, S.Franks
- pulsatile administration of LHRH for ovulation induction, H.Coelingh Bennink
- pulsatile gonadotrophin-releasing hormone GhRH treatment of idiopathic hypogonadotrophic hypogonadism - a model for studies of the neuroendocrine control of sexual maturation, D.I.Spratt et al
- LHRH analogues in the treatment of uterine fibroids, D.I.Healy et al
- LHRH analogues and the control of menstrual bleeding, R.W.Shaw
- LHRH analogues in the polycystic ovary syndrome, R.J.Chang
- the rationale and effect of LHRH analogues in the treatment of endometriosis, R.Gardner and R.W.Shaw
- the use of LHRH analogues in ovulation induction of multiple follicular growth for in-vitro fertilization, J.R.T.Coutts
- LHRH analogues for female contraception, H.M.Fraser et al
- analogues in precocious puberty, C.A.D.Brook
- LHRH analogues in the treatment of premenstrual syndrome, T.Backstrom et al.
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