Leukotrienes and lipoxygenases
著者
書誌事項
Leukotrienes and lipoxygenases
（Bioactive molecules, v. 11）
Elsevier , Distributors for the U.S. and Canada, Elsevier Science Pub. Co., 1989
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注記
Includes bibliographies and index
内容説明・目次
内容説明
Important advances have been made in the chemistry and biochemistry of the leukotrienes mainly as a result of the development of new biophysical and biochemical methodologies. The extraordinary effort of many scientists and the interactions of many scientific disciplines has created a vast amount of data and information and, with it, the need for a book addressing all aspects of this multidisciplinary field. This book has been written to respond to that need. It comprises six chapters which together provide a cohesive interdisciplinary coverage of the field, from the organic, analytical aspect to the biological sciences. Among the many subjects covered are many aspects of the leukotriene field which have not been covered in detail before, i.e. the numerous methodologies employed in the detection, localization and quantitation of lipoxygenase products; the role of leukotrienes in human disease states; leukotriene antagonists and lipoxygenase inhibitors, and potential therapeutic agents. The book brings together a wide variety of material to give a valuable overview of this important subject.
目次
1. Chemistry of the Leukotrienes and Other Lipoxygenase Products (C.K. Lau, J. Adams, Y. Guindon, J. Rokach). Introduction. Synthesis of peptide leukotrienes. Synthesis of LTB 4 and other diHETES. Synthesis of the HETES. The lipoxins: synthesis and identification of the natural products. 2. Biochemistry of the Lipoxygenase Pathways (A.L. Maycock, S.-S. Pong, J.F. Evans, R.A. Miller). Leukotriene biosynthetic pathways. Enzymes. Leukotriene receptors. Lipoxygenase products of cells. 3. Assay Methods for Various Lipoxygenase Products (R.N. Young, Y. Girard). Bioassay of leukotrienes. Analysis of leukotrienes by high performance liquid chromatography. Immunoassays of leukotrienes and related lipoxygenase products. Analysis of leukotrienes by mass spectrometry. 4. Pharmacology and Pathophysiology of Leukotrienes (T.R. Jones, G. Letts, C.-C. Chan, P. Davies). Introduction. Leukotrienes and respiratory function. Cardiovascular actions of the leukotrienes. Pharmacology of the leukotrienes: skin, eye and gastrointestinal tract. Leukotrienes and inflammation. Conclusion. 5. Evidence for the Involvement of Leukotrienes and Other Lipoxygenase Products in Disease States (A.W. Ford-Hutchinson). Introduction. Psoriasis. Other skin diseases. Inflammatory diseases. Bronchial asthma. Other allergic conditions. Shock reactions. Cardiovascular system. Conclusions. 6. Enzyme Inhibitors and Leukotriene Receptor Antagonists (B.J. Fitzsimmons, J. Rokach). Introduction. Enzyme inhibitors. Receptor antagonists. Conclusions. Conclusions. Subject Index.
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