Heparin : chemical and biological properties, clinical applications
著者
書誌事項
Heparin : chemical and biological properties, clinical applications
Edward Arnold, c1989
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注記
Includes bibliographies and index
内容説明・目次
内容説明
Heparins are naturally-occuring anti-clotting factors widely used in surgery and medicine. Here international contributors cover all basic and clinical properties of heparin, including practical and conceptual advances and its use in prophylaxis and extracorporeal treatment. This extensively referenced manual should be of interest to physicians working in the areas of haematology, biochemistry and surgery, as well as research scientists and pharmaceutical companies.
目次
- The history of heparin
- methods of structural analysis
- general physical properties
- chemical synthesis
- occurence and evolutionary aspects
- the mast cell system
- heparan sulphate protoglycans
- molecular organization and functions of heparan sulphate
- biosynthesis of heparin and related polysaccharides
- enzymes that degrade heparin and heparan sulphate
- molecular mechanisms of the accelerating effect of heparin on the reactions between antithrombin and clotting proteinases
- heparin co-factor II
- the biochemistry, cell biology and pathophysiology of anticoagulantly active heparin-like molecules of the vessel wall
- regulation of cellular proliferation
- aiogenesis
- lipases
- heparin binding and neutralizing proteins
- heparin assays and standardization
- pharmacokinetics
- antithrombotic mechanisms
- use of heparin as a prophylactic agent against venous thromboembolism
- monitoring heparin treatment
- heparin-induced bleeding and thrombocytopenia
- heparin as an anticoagulant during extracorporeal circulation
- surface-immobilized heparin.
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