Selected issues in risk assessment
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書誌事項
Selected issues in risk assessment
(Drinking water and health, v. 9)
National Academy Press, 1989
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注記
Includes bibliographies and indexes
内容説明・目次
内容説明
The National Research Council closes the landmark series Drinking Water and Health with Volume 9, published in two parts:
Part I: DNA Adducts provides an overview of DNA adducts and their effects on human health, explores the techniques currently in use for detecting them, offers an outlook on future toxicity testing, and lists specific recommendations for action.
Part II: Mixtures explores the issues surrounding multiple-chemical exposure from drinking water and reviews options for grouping compounds so their toxicity in mixtures can be reliably assessed. The book describes alternative approaches and considers the option of developing a modified "hazard index" for chemical compounds.
Table of Contents
Front Matter
Part I: DNA Adducts
Executive Summary
1 Biologic Significance of DNA Adducts and Protein Adducts
2 DNA-Adduct Technology
3 Conclusions and Recommendations
Appendix A: Drinking Water Contaminant Candidates for Development
of Baseline Data on Formation of DNA Adducts
Glossary
Biographical Sketches
Part II: Mixtures
Executive Summary
1 Introduction
2 Pharmacokinetics and the Risk Assessment of Drinking Water
Contaminants
3 Risk Assessment of Mixtures of Systemic Toxicants in Drinking
Water
4 Assessment of Exposure to Organophosphorus Conpounds, Carbamates,
and Volatile Organic Chemicals
5 Acetylcholinesterase Inhibitors: Case Study of Mixtures of
Contaminates with Similar Biologic Effects
6 Volatile Organic Compounds (VOCs): Risk Assessment of Mixtures of
Potentially Carcinogenic Chemicals
7 Conclusions and Recommendations for Research
Appendix A: An Approach for Risk Assessment of Volatile Organic
Chemicals in Drinking Water That Uses Experimental Inhalation Data
and a Physiologically Based Pharmacokinetic Model
Appendix B: A Model Illustrating Synergism
Appendix C: Models of Response: Dose Additivity and Response
Additivity
Biographical Sketches
Part III: Cumulative Index
Index
目次
- 1 Front Matter
- 2 Part I: DNA Adducts
- 3 Executive Summary
- 4 1 Biologic Significance of DNA Adducts and Protein Adducts
- 5 2 DNA-Adduct Technology
- 6 3 Conclusions and Recommendations
- 7 Appendix A: Drinking Water Contaminant Candidates for Development of Baseline Data on Formation of DNA Adducts
- 8 Glossary
- 9 Biographical Sketches
- 10 Part II: Mixtures
- 11 Executive Summary
- 12 1 Introduction
- 13 2 Pharmacokinetics and the Risk Assessment of Drinking Water Contaminants
- 14 3 Risk Assessment of Mixtures of Systemic Toxicants in Drinking Water
- 15 4 Assessment of Exposure to Organophosphorus Conpounds, Carbamates, and Volatile Organic Chemicals
- 16 5 Acetylcholinesterase Inhibitors: Case Study of Mixtures of Contaminates with Similar Biologic Effects
- 17 6 Volatile Organic Compounds (VOCs): Risk Assessment of Mixtures of Potentially Carcinogenic Chemicals
- 18 7 Conclusions and Recommendations for Research
- 19 Appendix A: An Approach for Risk Assessment of Volatile Organic Chemicals in Drinking Water That Uses Experimental Inhalation Data and a Physiologically Based Pharmacokinetic Model
- 20 Appendix B: A Model Illustrating Synergism
- 21 Appendix C: Models of Response: Dose Additivity and Response Additivity
- 22 Biographical Sketches
- 23 Part III: Cumulative Index
- 24 Index
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