Design of prodrugs
著者
書誌事項
Design of prodrugs
Elsevier , Sole distributors for the USA and Canada, Elsevier Science Pub. Co., 1985
- U.S.
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注記
Includes bibliographies and index
内容説明・目次
内容説明
Prodrug design comprises an important area of drug research that is concerned with the optimization of drug delivery. The book presents the basic principles of drug design and illustrates these principles with numerous examples. It provides a comprehensive review of the most recent literature on prodrugs, and is the first book dealing exclusively and extensively with all aspects of design and application. The book contains 11 chapters, each chapter written by outstanding scientists in the field. The following topics are treated: A comprehensive classification and evaluation of types of bioreversible derivatives for various functional groups and chemical entities occurring in drug substances. Design of prodrugs based on enzyme-substrate specificity. Pharmacokinetic aspects of prodrug design and evaluation. Sustained drug action accomplished by the prodrug approach. Site-specific drug delivery via prodrugs. Decreased toxicity and adverse reactions via prodrugs. Prodrugs for improved skin absorption. Prodrugs in cancer chemotherapy. Albumin as a natural carrier for drugs and enzyme therapy. Prodrugs versus soft drugs
目次
CONTENTS: 1. Design of prodrugs: Bioreversible derivatives for various functional groups and chemical entities (by H. Bundgaard). 2. Design of prodrugs based on enzyme-substrate specificity (by P.K. Banerjee and G.L. Amidon) 3. Pharmacokinetic aspects of prodrug design and evaluation (by R.E. Notari). 4. Sustained drug action accomplished by the prodrug approach (by A.A. Sinkula). 5. Site-specific drug delivery via prodrugs (by V.J. Stella and K.J. Himmelstein). 6. Decreased toxicity and adverse reactions via prodrugs (by G. Jones) 7. Prodrugs for improved formulation properties (by B.D. Anderson) 8. Prodrugs and skin absorption (by J. Hadgraft). 9. Prodrugs in cancer chemotherapy (by T.A. Conners) 10. Albumin: A natural carrier for drug and enzyme therapy (by M. J. Poznansky and D. Bhardwaj) 11. Prodrugs versus soft drugs (by N. Bodor).
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