Nucleotide analogues as antiviral agents
著者
書誌事項
Nucleotide analogues as antiviral agents
（ACS symposium series, 401）
American Chemical Society, 1989
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注記
"Developed from a symposium sponsored by the Divisions of Carbohydrate Chemistry and Medicinal Chemistry at the 196th National Meeting of the American Chemical Society, Los Angeles, California, September 25-30, 1988."
Includes bibliographies and indexes
内容説明・目次
内容説明
Largely in response to the AIDS epidemic, the amount of research directed toward the discovery of antiviral agents has greatly expanded. This new volume focuses on the potential of nucleotides to exert potent in vivo antiviral effects. It presents the findings of an international group of scientists who are carrying out research at the forefront of the nucleotide drug design. Twelve chapters describe many new concepts and results, much of which has been previously
unpublished. This book assembles a valuable collection of information, offering insight into this increasingly important research topic.
目次
- Inhibitors of Viral Nucleic Acid Polymerases. Pyrophosphate Analogues
- Synthesis of Acyclonucleoside Phosphonates for Evaluation as Antiviral Agents
- Structural Requirements for Enzymatic Activation of Acyclonucleotide Analogues and the Relationship of Their Mode of Antiherpetic Action
- Phosphonylmethyl Ethers of Nucleosides and Their Acyclic Analogues
- Synthesis and Antiviral Activity of Phosphonylmethoxyethyl Derivatives of Purine and Pyrimidine Bases
- Synthesis and Antiviral Activity of Nucleotide Analogues Bearing the (S)-(3-Hydroxy-2-Phosphonylmethoxy)propyl Moiety Attached to Adenine, Guanine, and Cytosine
- Design of Inhibitors of Herpes Simplex Virus Thymidine Kinase
- Nucleotides as Herpesvirus-Specific Inhibitors of Protein Glycosylation
- Antiviral Activity of the Nucleotide Analogue Ribavirin 5'-Sulfamate
- Design, Synthesis, and Antiviral Activity of Nucleoside and Nucleotide Analogues
- Nucleotide Dimers as Anti-HIV Agents
- Oligonucleotide Analogues as Potential Chemotherapeutic Agents
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