Fortschritte der Arzneimittelforschung Progress in drug research, or, Progrès des recherches pharmaoeutiques

著者

• Jucker, Ernest

書誌事項

Fortschritte der Arzneimittelforschung = Progress in drug research, or, Progrès des recherches pharmaoeutiques

hrsg. von Ernest Jucker

Birkhäuser, 1960-

• v. 30
• v. 31
• v. 32
• v. 33
• v. 34
• v. 35
• v. 36
• v. 37
• v. 38
• v. 39
• v. 40
• v. 41
• v. 42
• v. 43
• v. 44
• v. 45
• v. 46
• v. 47
• v. 48
• v. 49
• v. 50

注記

Text Language of Vol.49: English

内容説明・目次

巻冊次

v. 30 ISBN 9783764317522

内容説明

The editor is happy to present volume 30, a Jubilee volume, to the read- ers of "Progress in Drug Research". In the 27 years of its existence, this series of monographs has published more than three hundred suvey- articles covering almost all aspects of drug research, thus providing the opportunity of using the monographs for encyclopedic information. It is the editor's hope that the new volume, which contains 12 contribu- tions, will also be interesting and useful, both to those who are actively engaged in research and to those who wish to keep abreast of the latest developments and cannot afford the time to read all the numerous spe- cific puplications. The 12 contributions of volume 30 are particulary concerned with im- munopharmacology, progesterone receptors, brain neurotransmitters, hypertension, 5-hydroxytryptamine receptors, beta blockade, myo- cardial infarction, confirmation analysis malaria, tissue dwelling hel- minth parasites, oral anti diabetics; various problems of drug dis- covery are also dealt with. In addition, this volume contains a subject index, an alphabetical article index and also an author and subject in- dex for all the volumes so far puplished. On the occasion of this Jubilee Volume, the editor would like to take the opportunity of thanking not only the authors who were prepared to undertake the task of writing the present extensive surveys, but also to express his gratitute to all the previous authors who were also pre- pared to share their vast knowledge and experience with the readers.

目次

Serum electrolyte abnormalities caused by drugs.- The effect and usefulness of early intravenous beta blockade in acute myocardial infarction.- On conformation analysis, molecular graphics, fentanyl and its derivatives.- Brain neurotransmitters and the development and maintenance of experimental hypertension.- Progesterone receptor binding of steroidal and nonsteroidal compounds.- Serendipity and structured research in drug discovery.- Mechanism-based inhibitors of monoamine oxidase.- Advances in chemotherapy of malaria.- Orale Antidiabetika.- Immunopharmacological approach to the study of chronic brain disorders.- Recent advances in central 5-hydroxytryptamine receptor agonists and antagonists.- Advances in the treatment and control of tissue-dwelling helminth parasites.- Index, Vol. 30.- Index of Titles, Vol. 1-30.- Author and Paper Index, Vol. 1-30.

巻冊次

v. 31 ISBN 9783764318376

内容説明

Volume 31 of "Progress in Drug Research" contains 13 articles, a sub- ject index, an index for all articles that have been published so far in this series of monographs, as well as an author and subject index for all 31 volumes. The reviews in this volume are particularly concerned with the therapy of helminth diseases, with pyramidinones as biody- namic agents, and with quinolones which are of interest in the treat- ment of infections. For a deeper understanding of the pharmacokinet- ic actions of modem drugs, the articles on cooperative binding of drug molecules to DNA, on in vitro models for the study of antibiotic activi- ties, on inhibitors of the renin-angiotensin system, on GAB A-drug in- teractions, and on the mechanism of action of anxiolytic drugs provide a wealth offacts and new findings. The pharmacology of caffeine is re- viewed from the viewpoint of its role in combination with other phy- siologically active substances, and the chapter on high resolution nuc- lear magnetic resonance spectroscopy demonstrates the importance of this method in the development of new drugs. Finally, the article on light and dark touches border problems of the therapy of psychic dis- orders. With these contributions, the authors aim to summarize latest achieve- ments in important and actual fields of drug research. Researchers who are actively engaged in the same or in similar fields of research are sure to benefit from these efforts.

目次

* Inhalt * Sommaire.- Treatment of helminth diseases - challenges and achievements.- Ribonucleotide reductase inhibitors as anticancer and antiviral agents.- Pyrimidinones as biodynamic agents.- Enzyme inhibitors of the renin-angiotensin system.- Cooperative effects in drug-DNA interactions.- GABA-drug interactions.- Quinolones.- Risk assessment problems in chemical oncogenesis.- The pharmacology of caffeine.- Mechanism of action of anxiolytic drugs.- In vitro models for the study of antibiotic activities.- Light and dark as a "drug".- High resolution nuclear magnetic resonance spectroscopy of biological samples as an aid to drug development.- Index * Sachverzeichnis * Table des matieres, Vol. 31.- Index of titles * Verzeichnis der Titel * Index des titres, Vol. 1-31.- Author and paper index * Autoren- und Artikelindex * Index des auteurs et des articles, Vol. 1-31.

巻冊次

v. 32 ISBN 9783764319434

内容説明

In the first years of the existence of this series of monographs, during the so-called "Golden Age" of drug research, the majority of the pa- pers published were mainly concerned with the traditional domains of drug research, namely chemistry, pharmacology, toxicology and pre- clinical investigations. The series' aim was to give coverage to impor- tant areas of research, to introduce new active substances with thera- peutic potential and to call attention to unsolved problems. This objective has not changed. The table of contents of the present volume makes evident, however, that the search for new medicines has become increasingly complex, and additional, new disciplines have entered the research arena. The series now includes reviews on bio- chemical, biological, immunological, physiological and medicinal aspects of drug research. Researchers actively engaged in the various scientific fields forming the entity of drug research can benefit from the wealth of knowledge and experience of the respective authors, and will be assisted in their endeavour to discover new pharmaceutical agents. Those simply wanting to keep abreast of new developments in the complex, multi-discipline science can turn to the "Progress in Drug Research" volumes as an almost encyclopaedic source of information without having to consult the innumerable original publications. Volume 32 contains 12 reviews, a subject index, an index for the close to 400 articles published in the series so far, and an author and titles index for all 32 volumes.

目次

Sommaire.- Antigen-specific T-cell factors and drug research.- Implications of immunomodulant therapy in Alzheimer's disease.- Behavioral correlates of presynaptic events in the cholinergic neutrotransmitter system.- Surface interaction between bacteria and phagocytic cells.- The bacterial cell surface and antimicrobial resistance.- Hypertension: Relating drug therapy to pathogenetic mechanisms.- Adenosine receptors: Clinical implications and biochemical mechanisms.- Stereoselective drug metabolism and its significance in drug research.- Immunostimulation with peptidoglycan or its synthetic derivatives.- Organizing for drug discovery.- Approaches to the rational design of bacterial vaccines.- The chemistry of DNA modification by antitumor antibiotics.- Index Sachverzeichnis Table des matieres, Vol. 32.- Index of titles Verzeichnis der Titel Index des titres, Vol. 1-32.- Author and paper index Autoren- und Artikelindex Index des auteurs et des articles, Vol. 1-32.

巻冊次

v. 33 ISBN 9783764323066

内容説明

In the first years of the existence of this series of monographs, during the so-called "Golden Age" of drug research, the majority of the pa- pers published were mainly concerned with the traditional domains of drug research, namely chemistry, pharmacology, toxicology and pre- clinical investigations. The series' aim was to give coverage to impor- tant areas of research, to introduce new active substances with thera- peutic potential and to call attention to unsolved problems. This objective has not changed. The table of contents of the present volume makes evident, however, that the search for new medicines has become increasingly complex, and additional, new disciplines have entered the research arena. The series now includes reviews on bio- chemical, biological, immunological, physiological and medicinal aspects of drug research. Researchers actively engaged in the various scientific fields forming the entity of drug research can benefit from the wealth of knowledge and experience of the respective authors, and will be assisted in their endeavour to discover new pharmaceutical agents. Those simply wanting to keep abreast of new developments in the complex, multi-discipline science can turn to the "Progress in Drug Research" volumes as an almost encyclopaedic source of information without having to consult the innumerable original publications. Volume 33 contains 13 reviews, a subject index, an index for the close to 400 articles published in the series so far, and an author and titles index for all 33 volumes.

目次

Nicotine: an addictive substance or a therapeutic agent?.- Aspirin as an antithrombotic agent.- The mode of action of anti-rheumatic drugs. 1. Anti-inflammatory and immunosuppressive effects of glucocorticoids.- The use of neutrophils, macrophages and organ cultures to assess the penetration of human cells by antimicrobials.- RNA virus evolution and the control of viral disease.- Medicinal agents incorporating the 1,2-diamine functionality.- Adrenergic receptor research: Recent developments.- From podophyllotoxin glucoside to etoposide.- Emerging concepts towards the development of contraceptive agents.- Chemotherapy for systemic mycoses.- Effects of drugs on calmodulin-mediated enzymatic actions.- The significance of DNA technology in medicine.- Immunotherapy for leprosy and tuberculosis.- Index * Sachverzeichnis * Table des matieres, Vol. 33.- Index of titles * Verzeichnis der Titel * Index des titres, Vol. 1-33.- Author and paper index * Autoren- und Artikelindex * Index des auteurs et des articles, Vol. 1-33.

巻冊次

v. 34 ISBN 9783764323516

内容説明

Today's drug research is an extremely complex process which, apart from chemistry, pharmacology, toxicology and preclinical trials, in- cludes a variety of sciences such as biotechnology, biochemistry, im- munology, physics, biology and even computer sciences. The Table of Contents of the present volume demonstrates this situation and makes it evident that the individual researcher cannot possibly hope to keep abreast of all aspects of modern drug research. In this re- spect, the series of monographs "Progress in Drug Research" pro- vides valuable help and assistance. Those who simply wish to remain informed of the latest trends and developments in drug research can use the 34 volumes so far available as a source of almost encyclo- pedic character. Researchers actively engaged in the various scientific fields forming the entity of drug research can benefit from the wealth of knowledge and experience of the respective authors, and they will be assisted in their endeavour to discover new pharmaceutical agents. Moreover, the extensive bibliographies of the individual reviews provide an invaluable overview of the literature most pertinent to today's drug research. I should like to thank all the authors for their willingness to prepare the reviews and for sharing their insights and experience with the readers. Thanks are also due to Mrs L. Koechlin, H.-P. Thiir and A. Gomm of Birkhauser Publishers for their valuable help in the pre- paration of this volume.

目次

* Inhalt * Sommaire.- The use of quantum chemical methods to study molecular mechanisms of drug action.- Systemic cancer therapy: Four decades of progress and some personal perspectives.- Oligosaccharide chains of glycoproteins.- Pharmacology of migraine.- Natriuretic hormones.- Barbiturates and GABAA receptor complex.- Bioactive peptide analogs: In vivo and in vitro production.- Computer-assisted structure-antileukemic activity analysis of purins and their aza and deaza analogs.- Medicinal chemistry: A support or a driving force in drug research?.- Steroidogenic capacity in the adrenal cortex and its regulation.- Neuroimmune axis as a basis of therapy in Alzheimer's disease.- Fungal metabolites and Chinese herbal medicine as immunostimulants.- Progress in the chemotherapy of leprosy: Status, issues and prospects.- Present status of Leishmaniasis.- Index, Sachverzeichnis, Table des matieres, Vol. 34.- Index of titles, Verzeichnis der Titel, Index des titres, Vol. 1-34.- Author and paper index, Autoren- und Artikelindex, Index des auteurs et des articles, Vol. 1-34.

巻冊次

v. 35 ISBN 9783764324995

内容説明

Volume 36 of "Progress in Drug Research" contains 5 articles and the various indexes which facilitate its use and establish the connec- tion with the previous volumes. While all articles deal with some of the topical aspects of drug research, the contribution by Robert R. Ruffolo et al. on "Drug receptors and control of the cardiovas- cular system: Recent advances" is indeed in its own right a mono- graphic presentation of this important domain. The remaining four reviews provide an overview of the work in- volved in the search for new and better medicines, with a focus on chemical, pharmacological, toxicological, biological, biochemical and molecular modeling studies. In the 31 years this series has existed, the Editor has enjoyed the help and advice of many colleagues. Readers, the authors of the in- dividual articles, and, last but not least, the reviewers have all con- tributed greatly to the success of PDR. Although many comments received have been favorable, it is nevertheless necessary to analyze and to reconsider the current position and the direction of such a series. So far, it has been the Editor's aim to help spread informa- tion on the vast domain of drug research, and to provide the reader with a tool helping him or her to keep abreast of the latest develop- ments and trends.

目次

/ Inhalt / Sommaire.- Pharmacology of synthetic organic selenium compounds.- Opiate receptors: Search for new drugs.- Chemistry and pharmacology of cannabis.- Drug receptors and control of the cardiovascular system: Recent advances.- Molecular modeling and quantitative structure-activity analysis of antibacterial sulfanilamides and sulfones.- Index / Sachverzeichnis / Table des matieres, Vol. 36.- Index of titles / Verzeichnis der Titel / Index des titres, Vol. 1-36.- Author and paper index / Autoren- und Artikelindex / Index des auteurs et des articles, Vol. 1-36.

巻冊次

v. 36 ISBN 9783764325824

内容説明

Volume 36 of "Progress in Drug Research" contains 5 articles and the various indexes which facilitate its use and establish the connec- tion with the previous volumes. While all articles deal with some of the topical aspects of drug research, the contribution by Robert R. Ruffolo et al. on "Drug receptors and control of the cardiovas- cular system: Recent advances" is indeed in its own right a mono- graphic presentation of this important domain. The remaining four reviews provide an overview of the work in- volved in the search for new and better medicines, with a focus on chemical, pharmacological, toxicological, biological, biochemical and molecular modeling studies. In the 31 years this series has existed, the Editor has enjoyed the help and advice of many colleagues. Readers, the authors of the in- dividual articles, and, last but not least, the reviewers have all con- tributed greatly to the success of PDR. Although many comments received have been favorable, it is nevertheless necessary to analyze and to reconsider the current position and the direction of such a series. So far, it has been the Editor's aim to help spread informa- tion on the vast domain of drug research, and to provide the reader with a tool helping him or her to keep abreast of the latest develop- ments and trends.

目次

* Inhalt * Sommaire.- Pharmacology of synthetic organic selenium compounds.- Opiate receptors: Search for new drugs.- Chemistry and pharmacology of cannabis.- Drug receptors and control of the cardiovascular system: Recent advances.- Molecular modeling and quantitative structure-activity analysis of antibacterial sulfanilamides and sulfones.- Index * Sachverzeichnis * Table des matieres, Vol. 36.- Index of titles * Verzeichnis der Titel * Index des titres * Vol. 1-36.- Author and paper index * Autoren- und Artikelindex * Index des auteurs et des articles, Vol. 1-36.

巻冊次

v. 37 ISBN 9783764326265

内容説明

Volume 37 of "Progress in Drug Research" contains seven articles and the various indexes which facilitate its use and establish the connection with the previous volumes. While all articles deal with some of the topical aspects of drug research, the contribution by Al fred Burger on "Isosterism and bioisosterism in drug design" is of great value to those researchers who are engaged in drug design and wish to include isosteric considerations in establishing a work ing hypothesis. The remaining six reviews provide an overview of the work in volved in the search for new and better medicines. All these articles contain surveys of the latest findings in the respective domain. In the 31 years this series has existed, the Editor has enjoyed the help and advise of many colleagues. Readers, the authors of the in dividual reviews and, last but 'not least, the reviewers have all con tributed greatly to the success of PDR. Although many comments received have been favorable, it is nevertheless also necessary to an alyze and to reconsider the current position and the direction of such a series.

目次

* Inhalt * Sommaire.- Leukotriene antagonists and inhibitors of leukotriene biosynthesis as potential therapeutic agents.- Bacterial resistance to antibiotics: The role of biofilms.- Pharmacological properties of the natural polyamines and their depletion by biosynthesis inhibitors as a therapeutic approach.- Potassium channel openers: Airway pharmacology and clinical possibilities in asthma.- Antifungal chemotherapy: Are we winning?.- The hopanoids, bacterial triterpenoids, and the biosynthesis of isoprenic units in prokaryotes.- Isosterism and bioisosterism in drug design.- Index * Sachverzeichnis * Table des matieres, Vol. 37.- Index of titles * Verzeichnis der Titel * Index des titres * Vol. 1-37.- Author and paper index * Autoren- und Artikelindex * Index des auteurs et des articles, Vol. 1-37.

巻冊次

v. 38 ISBN 9783764327057

内容説明

Volume 38 of "Progress in Drug Research" contains four reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with novel quinolones and their antibacterial properties; neu- ropeptides and their immunoregulatory role; the new generation of monoamine oxidase inhibitors and their potential use in Parkin- son's disease; and with alternative approaches to the discovery of novel antipsychotic agents. These four reviews present important tools in the search for new and useful medicines. In the 32 years that "Progress in Drug Research" has existed, the Editor has enjoyed the valuable help and advice of many col- leagues. Readers, the authors of the reviews, and, last but not least, the reviewers have all contributed greatly to the success of the series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series.

目次

* Inhalt * Sommaire.- Foreword / Vorwort.- Fluorinated quinolones - new quinolone antimicrobials.- Immunoregulatory role of neuropeptides.- The new generation of monoamine oxidase inhibitors.- Alternative approaches to the discovery of novel antipsychotic agents.- Index * Sachverzeichnis * Table des matieres, Vol. 38.- Index of titles * Verzeichnis der Titel * Index des titres * Vol. 1-38.- Author and paper index * Autoren- und Artikelindex *.- Index des auteurs et des articles, Vol. 1-38.

巻冊次

v. 39 ISBN 9783764327170

内容説明

Volume 39 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the con- nection with the previous volumes. The articles in this volume deal with polyamines as tumor markers; the histamine (H3)-receptor and its role as a general regulatory system; with cytokines as immunosti- mulants and immunosuppressants as well as potential anticancer agents; with fibrinolysis and clinical use of thrombolytic agents; and with catechol O-methyltransferase and its inhibitors, which are of potential interest in the treatment of Parkinson's disease. An exten- sive review on antihistamines (HI) provides an excellent survey of this area in drug research. In the 32 years that "Progress in Drug Research" has existed, the Editor has enjoyed the valuable help and advice of many colleagues. Readers, the authors of the reviews, and, last but not least, the review- ers have all contributed greatly to the success of the series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series.

目次

/ Inhalt / Sommaire.- Polyamines as markers of malignancy.- Developments in antihistamines (H1).- The histamine H3-receptor: A target for developing new drugs.- Clinical application of cytokines for immunostimulation and immunosuppression.- Mechanisms of fibrinolysis and clinical use of thrombolytic agents.- The potential role of cytokines in cancer therapy.- Recent progress in understanding cholinergic function at the cellular and molecular levels.- Characteristics of catechol O-methyltransferase (COMT) and properties of selective COMT inhibitors.- The effects of NSAIDs and E-prostaglandins on bone: A two signal hypothesis for the maintenance of skeletal bone.- Index Sachverzeichnis Table des matieres, Vol. 39.- Index of titles Verzeichnis der Titel Index des titres Vol. 1-39.- Author and paper index Autoren- und Artikelindex Index des auteurs et des articles, Vol. 1-39.

巻冊次

v. 40 ISBN 9783764328504

内容説明

Volume 40 of "Progress in Drug Research" contains six reviews and the various indexes which facilitate its use and establish the connec- tion with the previous volumes. The articles in this volume deal with phosphodiesterase inhibitors and their therapeutic potential in asthma; peptide receptor ligand drugs; aldose reductase inhibitors; the design and discovery of new drugs by stepping-down and stepping-up approaches; new synthetic ligands for L-type voltage- gated calcium channels and with luteolytic agents in fertility regula- tion. III the 33 years that "Progress in Drug Research" has existed, the Edi- tor has enjoyed the valuable help and advice of many colleagues. Readers, the authors of the reviews, and last but not least, the review- ers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series.

目次

* Inhalt * Sommaire.- Isozyme-selective cyclic nucleotide phosphodiesterase inhibitors: Biochemistry pharmacology and therapeutic potential in asthma.- Toward peptide receptor ligand drugs: Progress on nonpeptides.- Aldose reductase inhibitors: Recent developments.- Design and discovery of new drugs by stepping-up and stepping-down approaches.- New synthetic ligands for L-type voltage-gated calcium channels.- Present status of luteolytic agents in fertility regulation.- Index * Sachverzeichnis * Table des matieres, Vol. 40.- Index of titles * Verzeichnis der Titel * Index des titres * Vol. 1-40.- Author and paper index * Autoren- und Artikelindex * Index des auteurs et des articles, Vol. 1-40.

巻冊次

v. 41 ISBN 9783764329259

内容説明

Volume 41 of "Progress in Orug Research" contains eight reviews and the various indexes which facilitate its use and establish the con- nection with the previous volumes. The articles in this volume deal with teratogenesis; nephrotoxicity; bacterial resistance to P. lactam antibiotics; eradication of diseases by vaccination; chirality and drug design; endogenous digitalis-like factors; erythropoietin; and sero- tonin (5HT)-antagonists. 3 All these articles give an excellent overview of the respective fields of research. In the 33 years that POR has existed, the Editor has enjoyed the valu- able help and advice of many colleagues. Readers, the authors of the reviews, and last but not least, the reviewers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series. So far, it has been the Editors intention to help disseminate informa- tion on the vast domain of drug research, and to provide the reader with a tool with which to keep abreast of the latest developments and trends. The reviews in POR are useful to the non-specialists, who can obtain an overview of a particular field of research in a relatively short time. The specialist readers of POR will appreciate the reviews' comprehensive bibliographies, and, in addition, they may even get fresh impulses for their own research.

目次

* Inhalt * Sommaire.- Chemical teratogenesis.- Drug nephrotoxicity - The significance of cellular mechanisms.- Bacterial resistance to ?-lactam antibiotics: Problems and solutions.- Eradication by vaccination: The memorial to smallpox could be surrounded by others.- Chirality and future drug design.- Endogenous digitalis-like factors.- Recent advances in erythropoietin research.- Structural modification patterns from agonists to antagonists and their application to drug design - A new serotonin (5HT3)-antagonist series.- Index * Sachverzeichnis * Table des matieres * Vol. 41.- Index of titles * Verzeichnis der Titel * Index des titres * Vol. 1-41.- Author and paper index * Autoren und Artikelindex *.- Index des auteurs et des articles, Vol. 1-41.

巻冊次

v. 42 ISBN 9783764329952

内容説明

Volume 42 of "Progress in Drug Research" contains seven reviews and the various indexes which facilitate its use and establish the con- nection with the previous volumes. The articles in this volume deal with organization and management of drug research; luteinizing hor- mone regulators; natural products as anticancer agents; flavonoids and their pharmacological activity; serenics in the control of mental disturbances; Transfer Factor and its application and with Transfer Factor in malignancy. In the 34 years that "Progress in Drug Research" has existed, the Edi- tor has enjoyed the valuable help and advice of many colleagues. Readers, the authors of the reviews, and last but not least, the review- ers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series. So far, it has been the Editors intention to help disseminate informa- tion on the vast domain of drug research, and to provide the reader with a tool with which to keep abreast of the latest developments and trends. The reviews in PDR are useful to the non-specialists, who can obtain an overview of a particular field of drug research in a rela- tively short time.

目次

* Inhalt * Sommaire.- Foreword.- Moral challenges in the organization and management of drag research.- Luteinizing hormone regulators: Luteinizing hormone releasing hormone analogs, estrogens, opiates, and estrogen-opiate hybrids.- Natural products as anticancer agents.- Carcinogenicity, mutagenicity and cancer preventing activities of flavonoids: A structure-system-activity relationship (SSAR) analysis.- Serenics.- Transfer factor 1993: New frontiers.- Transfer factor in malignancy.- Index * Sachverzeichnis * Table des matieres * Vol. 42.- Index of titles * Verzeichnis der Titel * Index des titres * Vol. 1-42.- Author and paper index * Autoren- und Artikelindex * Index des auteurs et des articles, Vol. 1-42.

巻冊次

v. 43 ISBN 9783764350420

内容説明

Volume 43 of "Progress in Drug Research" contains five reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with high cholesterol blood levels and other dyslipidemias; search of ideal antihypertensive drugs; the natural PQlyamines and the immune system; biologically active quinazolones and with production and action of interferons. In the 35 years the PDR has existed, the Editor has enjoyed the valuable help and advice of many colleagues. Readers, the authors of the reviews, and last but not least, the reviewers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series. So far, it has been the Editors intention to help disseminate information on the vast domain of drug research, and to provide the reader with a tool with which to keep abreast of the latest developments and trends. The reviews in PDR are useful to the non-specialist, who can obtain an overview of a particular field of drug research in a relatively short time. The specialist readers of PDR will appreciate the reviews' comprehensive bibliographies, and, in addition, they may even get fresh impulses for their own research. Finally, the readers can use the 43 volumes of PDR as an encyclopedic source of information.

目次

* Inhalt * Sommaire.- Drugs for treatment of patients with high cholesterol blood levels and other dyslipidemias.- In search of ideal antihypertensive drugs: Progress in five decades.- The natural polyamines and the immune system.- Biologically active quinazolones.- Production and action of interferons: New insights into molecular mechanisms of gene regulation and expression.- Addendum to "Natural products as anticancer agents" (PDR 42).- Index * Sachverzeichnis * Table des matieres, Vol.43.- Index of titles * Verzeichnis der Titel * Index des titres *Vol.1-43.- Author and paper index * Autoren und Artikelindex * Index des auteurs et des articles, Vol. 1-43.

巻冊次

v. 44 ISBN 9783764351496

内容説明

Contents: V. Zingel, C. Leschke and W. Schunack: Developments in research on histamine (H1) receptor agonists / P.D. Hoeprich: Antifungal chemotherapy / G. de Stevens: The diversity of heterocyclic compounds and their biological activities / R.M. Schultz: Newer antifolate compounds in cancer therapy / P.K. Mehrotra, S. Batra and A.P. Bhadun: Non-steroidal agents for regulation of the menstrual cycle / A.K. Saxena and M. Saxena: Developments in anti-convulsant drugs

目次

Heterocyclic diversity: The road to biological activity.- Developments in histamine H1-receptor agonists.- Antifungal chemotherapy.- Newer antifolates in cancer therapy.- Non-steroidal menses-regulating agents: The present status.- Developments in anticonvulsants.

巻冊次

v. 45 ISBN 9783764352127

内容説明

Volume 45 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with neuro- peptides as native immune modulators, with Calmodulin and with effects of cell stimuli and drugs on cellular activation, with recent advances in benzodiazepine receptor binding studies, with the medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor, with Serotonin uptake inhibitors, with computer-aided drug design, with natri- uretic hormones and with the recent developments in the chemotherapy of osteoporosis. In the 36 years that PDR has existed, the Editor has enjoyed the valu- able help and advice of many colleagues. Readers, the authors of the reviews and, last but not least, the reviewers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a series of monographs. So far, it has been the Editor's intention to help disseminate information on the vast domain of drug research, and to provide the reader with a tool with which to keep abreast of the latest developments and trends. The reviews in PDR are useful to the nonspecialist, who can obtain an overview of a particular field of drug research in a relatively short time.

目次

* Inhalt * Sommaire.- Neuropeptides as native immune modulators.- Calmodulin: Effects of cell stimuli and drugs on cellular activation.- Recent advances in benzodiazepine receptor (BZR) binding studies.- The medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor.- Serotonin uptake inhibitors: Uses in clinical therapy and in laboratory research.- Generation of new-lead structures in computer-aided drug design.- Natriuretic hormones II.- Recent developments in the chemotherapy of osteoporosis.- Index * Sachverzeichnis * Table des matieres, Vol. 45.- Index of titles * Verzeichnis der Titel * Index des titres Vol. 1-45.- Author and paper index * Autoren- und Artikelindex * Index des auteurs et des articles, Vol. 1-45.

巻冊次

v. 46 ISBN 9783764352981

内容説明

Volume 46 of "Progress in Drug Research" contains seven reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with endo- genous sodium pump inhibition, with neurotransmitters involved in the central regulation of the cardiovascular system, with leukotrienes and development of novel anti-inflammatory agents, with antithrombotic stra- tegies and drugs affecting the plasma fibrinogen levels, with natural ami- noglycosides and polyamines and their effects in the mammalian orga- nism, with the latest developments in antidepressant agents and with immunopharmacological and biochemical bases of Chinese herbal medi- cine. These reviews provide valuable information on several new deve- lopments in the complex domain of drug research. In the 37 years that PDR has existed, the Editor has enjoyed the valua- ble help and advice of many colleagues. Readers, the authors of the reviews and, last but not least, the reviewers have all contributed greatly to the success of this series of monographs. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such publi- cations.

目次

* Inhalt * Sommaire.- Endogenous sodium pump inhibition: Current status and therapeutic opportunities.- Neurotransmitters involved in the central regulation of the cardiovascular system.- Development of novel anti-inflammatory agents: A pharmacologic perspective on leukotrienes and their receptors.- Drugs affecting plasma fibrinogen levels. Implications for new antithrombotic strategies.- Aminoglycosides and polyamines: Targets and effects in the mammalian organism of two important groups of natural aliphatic polycations.- Recent developments in antidepressant agents.- Immunopharmacological and biochemical bases of Chinese herbal medicine.- Index * Sachverzeichnis *Table des matieres, Vol. 46 281.- Index of titles * Verzeichnis der Titel * Index des titres Vol. 1-46 287.- Author and paper index * Autoren- und Artikelindex * Index des auteurs et des articles, Vol. 1-46.

巻冊次

v. 47 ISBN 9783764352998

内容説明

Volume 47 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with inotropic steroids, with chemokines and their involvement in a wide range of inflam matory diseases, with the subclassification and nomenclature of ul- and Uz-adrenoceptors, with Chinese traditional medicine, with drug targets in the molecular pathogenesis of asthma, with cytokines and their therapeutic application in immunosuppression and immunostimulation, with alter native medicine and with the potential use of calcium blockers in psy chiatry. These reviews and the quotations of original articles provide the reader with valuable information on several new developments in the world-wide search for new and better medicines. In 1959, when the Editor started this series of monographs, it was his intention to help disseminate informa tion on the vast and fast growing domain of drug research. Already at that time,it was not possible to follow the major individual publications in this field, and the reader was thereby provided with a tool to keep abreast of the latest developments and trends. This goal remained unchanged over the last 37 years, and I believe that the reviews in PDR are useful to the non-specialist who can obtain an overview of a particular field of drug research in a relatively short time.

目次

* Inhalt * Sommaire.- In search of ideal inotropic steroids: Recent progress.- Chemokines as targets for pharmacological intervention.- Subclassification and nomenclature of ?1- and ?2-adrenoceptors..- Perspective and overview of Chinese traditional medicine and contemporary pharmacology.- Emerging drug targets in the molecular pathogenesis of asthma.- Therapeutic applications of cytokines for immunostimulation and immunosuppression: An update.- Alternative therapeutic modalities. Alternative medicine.- Calcium channel blockers in psychiatry.

巻冊次

v. 48 ISBN 9783764356712

内容説明

This series was founded in 1959, and its focus has shifted from medicinal chemistry to a much wider scope. It now encompasses all fields concerned with the development of therapeutic drugs and the elucidation of their mechanisms of action, reflecting the increasingly complex nature of modern drugs research. Invited authors write reviews on the following fields: biology, chemistry, biochemistry, physiology, immunology, pharmacy, toxicology, pharmacology, and clinical aspects. The books are linked by indexes in each volume, forming an almost encyclopaedic work.

巻冊次

v. 49 ISBN 9783764356729

内容説明

This volume contains reviews on a wide spectrum of topical areas in pharmacological and pharmaceutical research.

巻冊次

v. 50 ISBN 9783764358211

内容説明

Including details of current advances in drug research, this volume includes contributions by P.N. Kaul, M. Rohmer, T.D. Johnson, and R.W. Rockhold.

目次

• Drug discovery - past, present and future, P.N. Kaul
• isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs?, M. Rohner
• endothelium-derived hyperpolarizing factor - a critical appraisal, G. Edwards and A.H. Weston
• glutamatic involvement in psychomotor stimulant action, R.W. Rockhold
• the identification and development of antiviral agents for the treatment of chronic hepatitis B virus infection, J.M. Colacino and K.A. Staschke
• polyamines and cerebal ischemia, T.D. Johnson.

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詳細情報

• NII書誌ID(NCID): BA08662035
• ISBN:
  • 3764317523
  • 3764318376
  • 3764319437
  • 376432306X
  • 3764323515
  • 3764324996
  • 3764325828
  • 3764326263
  • 3764327057
  • 3764327170
  • 3764328509
  • 3764329254
  • 3764329955
  • 3764350423
  • 3764351497
  • 3764352124
  • 3764352981
  • 376435299X
  • 3764356715
  • 3764356723
  • 3764358211
• 出版国コード: sz
• タイトル言語コード: ger
• 本文言語コード: ger
• 出版地: Basel
• ページ数/冊数: v.
• 大きさ: 25 cm