Design of enzyme inhibitors as drugs
著者
書誌事項
Design of enzyme inhibitors as drugs
Oxford University Press, 1989
大学図書館所蔵 全18件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographies and index
内容説明・目次
内容説明
A collection of essays, based on research exploring ways in which the inhibition of the action of particular enzymes in the body can produce a desired therapeutic effect. The book contains accounts of the major target enzymes and their inhibitors which are currently the focus of research. The introductory chapters describe the underlying physical and chemical processes of enzyme inhibition and the general principles of inhibitor design using the many sophisticated and computer-based techniques that are now available. Subsequent chapters discuss in detail the wide range of individual target enzymes and inhibitors which are either in clinical use or are under study, emphasizing the factors which affect their usefulness in the clinical context - bioavailability, pharmaco kinetics and side-effects.
目次
- Introduction to the use of enzyme inhibitors as drugs
- general approaches to the design of inhibitors
- inhibitors of the Renin-Angiotens in system enzymes
- lactamase inhibitors
- enkephalinase inhibitors as drugs
- monoamine oxidase inhibitors
- polyamine oxidase inhibitors
- new developments in enzyme activated irreversible inhibitors of pyridoxal phosphate-dependent enzymes of therapeutic interest
- cholinesterase and esterase inhibitors and reactivators of organophosphorus-inhibited esterases
- inhibitors of enzymes of the arachidonic acid metabolic pathways
- selective inhibitors of dihydrofolate reductases
- the antibacterial sulphonamides
- inhibitors of enzymes of the de novo pyrimidine pathway
- inhibitors of purine biosynthesis
- inhibitors of Na+, K+ ATpase
- inhibitors of steriod biosynthesis
- inhibitions of enzymes involved in bacterial cell wall synthesis
- inhibition of proteinases
- development of selective inhibitors of calmodulin-dependent phosphodiesterase and adenylate cyclase
- inhibitors of carbonic anhydrase
- inhibition of intracellular methyl transfer and aminopropyl transfer reactions by analogues of substrates, products, and transition states
- inhibitors of some other target enzymes as potential clinical agents. Index.
「Nielsen BookData」 より