Cyclosporin : mode of action and clinical applications
著者
書誌事項
Cyclosporin : mode of action and clinical applications
Kluwer Academic Publishers, c1989
大学図書館所蔵 全6件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographies and index
内容説明・目次
内容説明
Cyclosporin has had a remarkable effect on clinical organ transplantation. Prior to its introduction, considerable advances had been made in the grafting of vital organs, particularly the kidney, heart and liver. In many developed countries, however, transplantation was not considered wo-rthwhile in terms of gain for the investment of resources. The improved results of kidney grafts following the use of cyclosporin has changed this attitude. For all types of organ transplantation, cyclosporin has resulted in an improvement of functional graft survival and has allowed a reduction in steroid dose and, in some cases, no steroids at all. It has permitted the first successful experimental transplantation of the heart and lungs in primate species by Reitz and colleagues and their results were applied directly to the clinic. It was largely due to the introduction of cyclosporin that the Washington Consensus Meeting on Liver Transplantation came to a favourable recommendation and the result has been the proliferation of units performing liver transplantation, approximately fifty in North America and another fifty in Europe, where previously there had been a handful. Having been involved in cyclosporin for organ grafting from the beginning, I have been able to witness these developments which have far exceeded my expectations once the nephrotoxicity of cyclosporin was demonstrated in man. It is fitting that Dr.
目次
1 Inhibitory effects of cyclosporin A on lymphocyte activation.- 2 Effect of cyclosporin A on the immune response: pivotal role of the interleukin-2/interleukin-2 receptor autocrine pathway.- 3 Influence of cyclosporin A on humoral immunity and on B lymphocyte activation.- 4 The influence of cyclosporin A on T cell activation, cytokine gene expression and cell-mediated immunity.- 5 Cyclosporin A and tolerance induction in experimental animals.- 6 Prevention of graft rejection by cyclosporin A in man.- 7 Cyclosporin A and bone marrow transplantation.- 8 Cyclosporin A and intraocular inflammatory disease.- 9 Cyclosporin A in insulin-dependent diabetes.- 10 Cyclosporin A and skin disease.- 11 Cyclosporin A (Sandimmun (R)) in autoimmune disorders.- 12 Pharmacokinetics of cyclosporin A.- 13 Cyclosporin A metabolism and drug interactions.- 14 Pathological effects of cyclosporin A in experimental models.- 15 Pathological effects of cyclosporin A in clinical practice.
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