Hematopoiesis : proceedings of a UCLA Symposium held at Tamarron, Colorado, February 20-26, 1989
著者
書誌事項
Hematopoiesis : proceedings of a UCLA Symposium held at Tamarron, Colorado, February 20-26, 1989
（UCLA symposia on molecular and cellular biology, new ser.,
Wiley-Liss, c1990
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注記
Proceedings of the UCLA Symposium on Hematopoiesis
Includes bibliographical references and index
内容説明・目次
内容説明
Chronicles the latest advances in the cellular, molecular and biochemical analysis of hematopoiesis, including findings from both basic research and clinical medicine. In reporting new methodology for the isolation and characterization of stem cells, it details the successful in vitro establishment of hematopoietic and stromal cell lines, that have facilitated analysis of the complex interactions between growth factor-producing accessory cells and target hematopoietic cells. In probing the molecular biology, the book assesses progress in the dissection of the mechanisms controlling the expression of the hematopoietic growth factor genes. It highlights new data relating to oxygen regulation of erythropoietin gene expression and transcription factors controlling IL-1 or GM-CSF gene expression. In exploring receptor physiology, "Hematopoiesis" features considerable advances in the characterization of receptors for GM-CSF and IL-3 and knowledge gained from the cloned gene for the erythropoietin receptor.
Recent results from clinical studies with different hematopoietic growth factors reveal that patients receiving G-GSF, GM-CSF or erythropoietin in North America, Europe and Japan are clearly benefiting from treatment with these agents.
目次
- Hematopoietic Growth Factors: Structure and Function
- Cytokine Gene Expression
- Hematopoietic Growth Factor Receptors
- Stromal Cells and the Hematopoietic Microenvironment
- Leukemic Cells and Cell Lines
- Hematopoietic Growth Factors: In Vivo Models and Clinical Studies.
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