Mouse liver carcinogenesis : mechanisms and species comparisons : proceedings of the symposium held in Austin, Texas, November 30-December 3, 1988
著者
書誌事項
Mouse liver carcinogenesis : mechanisms and species comparisons : proceedings of the symposium held in Austin, Texas, November 30-December 3, 1988
（Progress in clinical and biological research, v. 331）
Wiley-Liss, c1990
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注記
Includes bibliographical references
Conference hosted by the Science Park-Research Division of the University of Texas M.D. Anderson Cancer Center in Smithville, Tex
内容説明・目次
内容説明
This volume presents recent studies on the biologic importance of chemically or environmentally induced mouse liver tumors to human cancer risk assessment. It examines the mechanisms and scientific controversies surrounding the induction of mouse liver tumors and offers proposals for continued study. Investigators from universities, regulatory agencies, industrial and public interest research groups review and analyze detailed findings on mouse liver carcinogenesis in order to better understand the pertinent mechanisms and their relative importance to humans and other species. The volume addresses mouse liver carcinogenesis at several levels. There are extensive discussions of the cellular, biochemical and molecular events leading to initiation, promotion and neoplastic progression. Investigators evaluate and compare studies that implement varying exposure to chemicals.
目次
- Detailed Overviews of the Mouse Liver as an Experimental System
- Use of Mouse Liver Tumor Data in Risk Assessment
- Correlations between Tumors in Different Sites and Species
- Various Tumor Models, Including Transplacental and Perinatal
- Morphological Changes and Histological Markers
- DNA and Chromosome Alterations, Including Oncogene Activation
- Cell Proliferation and Cell Death.
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