Molecular mechanisms in muscular contraction
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Bibliographic Information
Molecular mechanisms in muscular contraction
（Topics in molecular and structural biology, 13）
Macmillan, c1990
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Includes bibliographies and index
Description and Table of Contents
Description
Muscle cells provide a unique probe into the motile properties of all living systems. A full understanding of molecular mechanism within muscle cells is therefore important to many areas of biological research. It is now nearly 40 years since the postulation of the sliding filament model of muscle contraction yet only recently has sufficient evidence been produced to support a convincing model. This book marks a turning point in muscle research. It reviews the evidence that myosin cross-bridges do indeed swing on actin filaments during contraction, and starts to tackle the problems this raises: what are the geometrics of the attached states of cross-bridges on actin? How many states are there? What is the sequence of molecular events during muscle activation? And is the primary source of muscular force cross-bridge swinging of Helix-coil transition?
Table of Contents
- Part 1 Organization and structure of actomyosin systems: motile systems
- filament lattice organization in striated muscles
- structure and components of the A-band
- models for the mechanism of force production
- actin filament structure and myosin head labelling
- actin filament organization and Z-band structure
- lattice restrictions on the actin-myosin interaction. Part 2 The nature of the actin molecule: sequence differences among actin isoforms
- post-translational modifications of actin
- chemistry of actin polymerization
- structure determination. Part 3 The structure of F-actin calculated from X-ray fibre diagrams and the 0.6mm crystal structure: fitting fibre diffraction results. Part 4 Muscle mechanics and biochemical kinetics: actomyosin ATPase cycle in solution
- mechanical determination of crossbridge kinetics in muscle
- crossbridge turnover kinetics in muscle
- correlation of mechanical, biochemical and structural data
- implications of recent mechanical, structural and biochemical studies for some unresolved questions. Part 5 Crossbridge patterns in defined static states in insect asynchronous flight muscle: types of thin section
- the ATP-relaxed state
- rigor state
- model for the distribution of myosin heads in rigor insect flight muscle
- AMP.PNP-induced states. Part 6 Nuclear magnetic resonance studies of calcium modulated proteins and actin-myosin interaction: the nature of proteins
- the nature of cations and anions involved with contractile devices
- NMR spectroscopic approach to the definition of protein energetics. Part 7 Crossbridge movements monitored by extrinsic probes: theory
- methods
- fluorescence polarization from muscle crossbridges
- electron spin resonance
- spectroscopic studies of actin involvement in contraction. Part 8 Functional aspects of the myosin rod in contraction: physico-chemical properties of the myosin rod
- structural states of the myosin rod in rigor muscle
- dynamics of the myosin rod in activated muscle and functional aspects in contraction. Part 9 Equatorial X-ray diffraction studies of single-skinned muscle fibres: technical considerations
- equatorial diffraction from resting single-skinned fibres
- equatorial diffraction from Ca2+ activated single fibres. Part 10 Static and time-resolved X-ray diffraction studies of contracting fish muscle: X-ray diffraction from turbot fin muscle
- equilibrium crossbridge states in fish muscle
- mass transients between steady states
- unexpected changes in fish muscle structure on activation - a possible crosssbridge cycle in fish muscle.
by "Nielsen BookData"