Mediators of the inflammatory process
Author(s)
Bibliographic Information
Mediators of the inflammatory process
（Handbook of inflammation, v. 6）
Elsevier , Sole distributors for the USA and Canada, Elsevier Science Pub. Co., 1989
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Inflammation can be defined as a generalized, nonspecific but beneficial response of tissues to injury. The essential, protective role of inflammation can easily be seen in the life-threatening genetic diseases in which key elements of the inflammatory reaction are missing or defective. The drive to understand the underlying control processes and underlying mechanisms derives, however, more from the pathological perspective than from elucidating defense of the host to injury, and has prompted an enormous effort on the part of the pharmaceutical industry to develop efficient antagonists and inhibitors of the molecules involved in these reactions; the inflammatory mediators. This volume is intended by the authors to provide information on groups of mediators of inflammation in general, and where possible to stimulate interest and comments on the possibilities for participation of these communication molecules, mediators, in the complex but fascinating process of inflammation.
Table of Contents
Introduction. 1. Mediators of the inflammatory process: prostanoids (K.L. Brigham). 2. Leukotriene B 4 (R.R. Gorman). 3. Sulfidopeptide leukotrienes and airway function (M.K. Hodges and J.M. Drazen). 4. Products of 12- and 15-lipoxygenase (W.R. Henderson Jr.). 5. Platelet activating factor: synthesis, metabolism, and relationship to arachidonate products (F.H. Chilton). 6. PAF-acether: biology, receptors and antagonists (B.B. Vargaftig et al.). 7. Transcellular biosynthesis of eicosanoids and inflammation (R.C. Murphy, F.A. Fitzpatrick and J. Maclouf). 8. Oxygen radicals as "mediators of inflammation" (J.S. Warren, P.A. Ward and K.J. Johnson). 9. Mediators of the inflammatory process: vasoactive amines (N.R. Zahniser and D.R. Metcalf). 10. Roles for kinins in inflammation (J.M. Stewart). 11. Neuropeptides in inflammation and tissue repair (S.M. Aguayo and Y.E. Miller). 12. Interleukins (R.J. Shaw and R.A.F. Clark). 13. Role of platelet-derived growth factor and other growth factors in inflammation (N.F. Voelkel). 14. The roles of colony-stimulating factors and interferons in inflammation (D.M. Pinson and S.W. Russell). 15. Extracellular matrix components as mediators of inflammation (R.M. Senior et al.). 16. Bacterial lipopolysaccharide, a mediator of inflammation (M.J. Pabst and R.B. Johnston Jr.). Subject index.
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