Intervening sequences in evolution and development
著者
書誌事項
Intervening sequences in evolution and development
Oxford University Press, 1990
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注記
Includes bibliographies and index
内容説明・目次
内容説明
Biologists have long been puzzled by the peculiar arrangement of genes on the strands of DNA found in the cell. In particular, many genes are interrupted by non-coding regions - intervening sequences of introns - that nonetheless function in some developmental systems and probably were involved in the evolution of the earliest genes. Furthermore, biologists did not anticipate the ubiquitous existence of introns on either functional or evolutionary grounds. Thus, many questions about the evolution and operation of the genetic system remain unresolved. In Intervening Sequences in Evolution and Development , issues of fundamental importance to molecular, developmental and evolutionary biology are addressed as follows: gene structure in primordial organisms; the relationship between gene and protein structure; and gene regulation via differential RNA processing.
目次
- Michael G. Rossman: Introductory comments on the function of domains in protein structure
- S.K. Holland, & C.C.F. Blake: Proteins, exons, and molecular evolution
- W. Ford Doolittle: Understanding introns: origins and functions
- Edwin M. Stone, & Robert J. Schwartz: Intron-dependent evolution of progenotic enzymes
- Joseph P. Stein, Maxwell J. Scott, & Bert W. O'Malley: Intervening sequences in molecular evolution
- Philip S. Perlman, Craig Peebles, & Charles Daniels: Types of introns and splicing mechanisms
- Christopher W.J. Smith, David Knaack, & Bernardo Nadal-Ginard: Alternative mRNA splicing in the generation of protein diversity and the control of gene expression.
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