Proto-oncogenes in cell development
著者
書誌事項
Proto-oncogenes in cell development
(Ciba Foundation symposium, 150)
Wiley, 1990
大学図書館所蔵 全16件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Editors: Greg Bock and Joan Marsh
"Symposium on Proto-oncogenes in Cell Development, held at the Ciba Foundation, London, 19-21 September 1989"--Contents p
"A Wiley-Interscience publication."
Includes bibliographical references
内容説明・目次
内容説明
Proto-Oncogenes in Cell Development Chairman: T. Hunter 1990 The role of certain genes in the uncontrolled cellular growth that constitutes cancer has been studied intensively for several years. These oncogenes are often viral genes that have been integrated into the genome of the cell. It is now known that these viral genes are mutated versions of normal cellular genes involved in the control of growth and development. The mutant genes fail to respond to regulatory signals in the cell, resulting in unrestrained proliferation. In this book the role of these cellular or proto-oncogenes in normal cell growth is investigated. Several of the proto-oncogenes encode growth factors or their receptors. The latter usually possess tyrosine kinase activity, which phosphorylates specific cytoplasmic proteins thereby initiating the transmission of the signal from the cell membrane to the nucleus. The mechanisms by which this is achieved, and particularly the regulatory aspects, are covered in this book. There are also reports of how phosphorylation of other amino acid residues is used to regulate this transfer of information.
The external stimulus received by the cell results in altered gene expression in the nucleus. The role of nuclear proteins in controlling gene activity is described. Many of the proto-oncogenes are now being found to affect cellular differentiation; the book includes reports on their effects in several specialized tissue types. Finally, the role of proto-oncogenes in the development of the organism as a whole is discussed. These studies are more preliminary but provide an exciting pointer to the direction of future research. Related Ciba Foundation Symposia: No 116 Growth factors in biology and medicine Chairman: Sir Michael Stoker 1985 ISBN 0 471 91085 6 No 142 Genetic analysis of tumour suppression Chairman: E. G. Stanbridge 1989 ISBN 0 471 92299 4 No 144 Cellular basis of morphogenesis Chairman: L. Wolpert 1989 ISBN 0 471 92306 0
目次
Partial table of contents: Structural and Functional Aspects of Platelet-Derived Growth Factor and Its Receptors (B. Westermark, et al.). Construction of Mammalian Cell Lines with Indicator Genes Driven by Regulated Promoters (J. Meinkoth, et al.). Molecular Biology of the hst-1 Gene (T. Sugimura, et al.). Role of Receptor Tyrosine Kinases During Drosophila Development (E. Hafen & K. Basler). Cellular Proteins that Are Targets for Transformation by DNA Tumor Viruses (K. Buchkovich, et al..). Index of Contributors. Subject Index.
「Nielsen BookData」 より