書誌事項

Glutathione S-transferases and drug resistance

edited by J.D. Hayes, C.B. Pickett, and T.J. Mantle

Taylor & Francis, 1990

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注記

Based on the Third International Conference on GST, held in Aug. 1989 at the Royal College of Physicians (Edinburgh) under the auspices of the Dept. of Clinical Chemistry, University of Edinburgh

Includes bibliographical references

内容説明・目次

内容説明

The proceedings of the 3rd International GST Conference held at the Royal College of Physicians, Edinburgh, on 20-30 August 1989. The conference was divided into five sessions - enzymology, toxication, control of expression, drug resistance and clinical applications of GST.

目次

  • Part 1 Enzymology of the glutathione S-transferases, the glutathione S-transferases and their contribution to drug resistance in nature, J.D.Hayes, C.B.Pickett and T.J.Mantle
  • rapid purification of glutathione S-tranferases by gradient affinity elution of the glutathione-agarose and the S-hexylglutathione-agarose chromatography matrics, J.D.Hayes. Part 2 roles of GST in toxication and detoxication, reaction of glutathione tranferases, a pattern for the enzymes by detoxication, W.B.Jakoby
  • GSTs and protection against oxidative stress, B.Ketterer, D.J.Meyer, J.B.Taylor, S.Pemble, B.Coles and G.Fraser. Part 3 Control of GST expression
  • regulation of glutathione S-tranferases Ya subunit gene expression by planar aromatic compounds, T.H.Rushmore and C.B.Pickett
  • regulation of the induction of glutathione transferases and NAD(P)H - quinone reductase by glutathione transferases substrates, P.Talalay and S.R.Spencer. Part 4 Models of drug resistance, a mechanisms of anticancer drug resistance, A.L.Harris
  • glutathione S-transferases in resistance to chemotherapeutic drugs, C.R.Wolf, C.J.Wareing, S.M.Black and J.D.Hayes. Part 5 Clinical applications of GST measurements and prevention of resistance
  • glutathione S-transferases and (pre)neoplasia, K.Sato, K.Satoh, S.Tsuchida, I.Hatayama, K.Tamai and H.Shen.

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