Garrod's inborn factors in disease : including an annotated facsimile reprint of The inborn factors of disease by Archibald E. Garrod
Author(s)
Bibliographic Information
Garrod's inborn factors in disease : including an annotated facsimile reprint of The inborn factors of disease by Archibald E. Garrod
（Oxford medical publications）（Oxford monographs on medical genetics, no. 16）
Oxford University Press, 1989
- Other Title
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Inborn factors in disease
- Uniform Title
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Inborn factors in disease
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Note
A companion vol. to: Garrod's inborn errors of metabolism
Includes bibliographies
Description and Table of Contents
Description
Sir Archibald Garrod had a distinguished career in medicine and maintained a lifelong interest in biochemistry. His first book, "Inborn Errors of Metabolism", was published in 1909 and established chemical individuality as the paradigm of Mendelian variation. In the years that followed, Garrod continued to develop the theme of the relationship between chemical individuality and disease and at the end of his career he wrote "Inborn Factors in Disease", in which he set out his belief that chemical individuality could result in individuals having a predisposition to certain diseases. This was published in 1931, but was not well received. Today, the importance of genetic disease is recognized and this work, which contains a complete facsimile reprint of the original text, now represents the origin of modern molecular medicine and genetics in medicine.
Table of Contents
- Part 1 The basic priniciples: health and disease
- the chemical basis of individuality
- evolution - disease
- inheritance of morbid liabilities. Part 2 The several kinds of predisposition: structure and form in relation to disease
- tissue defects - abiotrophies
- errors of metabolism
- the inborn factors in infective diseases
- idiosyncracies
- genetic predisposition after Garrod.
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