The physics and radiobiology of fast neutron beams

著者

• Bewley, David K.

書誌事項

The physics and radiobiology of fast neutron beams

D.K. Bewley

（Medical science series）

A. Hilger, c1989

注記

Bibliography: p. 168-175

Includes index

内容説明・目次

内容説明

Over fifty years have passed since the first patient was treated with fast neutrons, but this form of therapy is still a matter of bitter dispute. Neutron generators have been installed in many countries and now patients can be treated with equipment that is technically similar to modern megavoltage x-ray equipment. The Physics and Radiobiology of Fast Neutron Beams presents a full discussion of the physical and radiobiological factors governing the production and use of fast neutron beams for therapy. The book discusses vastly improved neutron generators, advances in the standardization of dosimetric methods, and the specification of radiation quality. In addition, it explores nuclear methods of analysis, particularly neutron activation analysis in vivo. Influencing the place of radiotherapy with neutrons and other heavy particles, the radiobiological factors governing the treatment of cancer with radiation are examined. The author also studies the radiation hazard of neutrons, a matter of importance in the use of neutrons for chemical analysis in vivo. The Physics and Radiobiology of Fast Neutron Beams will be a valuable introduction to the subject for radiotherapists, medical physicists, radiographers, and radiobiologists new to the field. The book is also a useful summary of current knowledge for those already established in the use of fast neutrons for medical purposes.

目次

PRODUCTION OF NEUTRON BEAMS Basic properties of the neutron Neutron sources Comparison of generators for neutron therapy Comparison of generators for nuclear methods of analysis (activation) NEUTRON INTERACTIONS AND KERMA Cross sections Kerma Neutron spectra in terms of soft-tissue kerma DOSIMETRY Methods of dosimetry Principles of mixed-field dosimetry Absolute instruments Relative instruments: ionization chambers Separation of neutron and gamma-ray components Miscellaneous dosimetric methods Neutron dosimetry intercomparisons PENETRATION IN TISSUE Phantom materials Measurement of dose distributions Examples of dose distributions Backscatter Gamma radiation Target thickness and filtration Transition dose Inhomogeneities SHIELDING, COLLIMATION, AND RADIATION PROTECTION Doses far outside the beam Induced radioactivity Doses received by staff due to activation Room shielding Protection measurements RADIATION QUALITY Neutron spectra Quality from secondary charged particles RADIOBIOLOGY General concepts RBE and neutron energy Chemical modifiers of radiation response RBE and position in the cell cycle Repair of damage after photons and neutrons RBE and dose level RBE in relation to tissue and end-point Tumors RBE and secondary charged-particle equilibrium The gamma-ray component NEUTRON THERAPY Effects of hypoxia Radioresistant tumors Growth rates Selection of cases Treatment schedules Other forms of high-LET radiation THE RADIATION HAZARD OF NEUTRONS Introduction Quality factor Use of chromosome aberrations to assess dose-equivalent RBE values for life-shortening and carcinogenesis Doses and risks to patients investigated by nuclear methods of analysis (activation) SUMMARY AND CONCLUSIONS REFERENCES INDEX

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詳細情報

• NII書誌ID(NCID): BA10634269
• ISBN:
  • 085274093X
• LCCN: 89007579
• 出版国コード: uk
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Bristol
• ページ数/冊数: xii, 179 p.
• 大きさ: 24 cm
• 分類:
  • LCC : RM862.F37
  • DC20 : 615.8/42
• 件名:
  • LCSH : Fast neutrons -- Therapeutic use
  • LCSH : Fast neutrons -- Physiological effect
  • LCSH : Medical physics
• 親書誌ID:
  • BA0074174X