Hereditary colorectal cancer : proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4), November 9-11, 1989, Kobe Japan
著者
書誌事項
Hereditary colorectal cancer : proceedings of the Fourth International Symposium on Colorectal Cancer (ISCC-4), November 9-11, 1989, Kobe Japan
Springer-Verlag, c1990
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注記
"Sponsored by the International Committee [f] or ISCC-4 at Hyogo College of Medicine"--P
Includes index
内容説明・目次
- 巻冊次
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:wb ISBN 9783540700524
内容説明
This text covers subjects pertaining to colorectal cancer genetics. It captures the active thinking of many of the investigators on this subject, with more than 70 contributors presenting research from around the world. The topics inlcude genetic heterogeneity, pathology, hereditary colorectal cancer syndrome classification, biomarker research, screening strategies, and the registration of cancer-prone families. This is a publication which provides an eclectic approach to the field of colorectal cancer genetics.
- 巻冊次
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:ja ISBN 9784431700524
内容説明
Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen- tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino- genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists.
Morphological characteri- zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ- ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.
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