Thymus dependency
著者
書誌事項
Thymus dependency
（Contemporary topics in Immunobiology, v. 2）
Plenum Press, 1973
大学図書館所蔵 件 / 全7件
-
該当する所蔵館はありません
- すべての絞り込み条件を解除する
注記
Includes bibliographies
内容説明・目次
内容説明
This second volume of Contemporary Topics in Immunobiology considers many aspects of thymus dependency in order to exemplify the role of the thy- mus in different species and different immunological responses. It is not in- tended to be a compendium of the responses which have been shown to be thymus dependent but rather to illustrate for the reader the criteria he should apply in thinking about the significance of the thymus in immune responses. We are grateful to the editors and publishers of the Annals of the New York Academy of Science, the Australian Journal of Experimental Biology and Medical Science, Clinical and Experimental Immunology, Immunology, the Journal of Experimental Medicine, the Journal of Immunology, Laboratory Investigation, Nature, and the Proceedings of the Royal Society of Medicine and to Springer-Verlag, Berlin, for permission to reproduce illustrations. Specific references are given in the text. We would also like to thank the contributors for their time and energy and willingness to submit to the editorial red pencils. The exercise of these censori- ous instruments meant that the manuscripts had to be reorganized and retyped. Mrs. J. Pettis, Mrs. A.
Inglefield, and Miss M. Butt all helped, and we are most grateful to them. A.J.S.D. R.L.e.
目次
1. The Thymus and Lymphomyeloid System in Poikilothermic Vertebrates.- The Thymus and Transplantation Immunity.- Thymectomy in Anurans.- Thymectomy in Urodeles.- Antigen Trapping in Lymphomyeloid Organs of Anurans.- Thymus, Spleen, and Lymph Gland Control of Immunoglobulin Synthesis in Larval Amphibians.- Antibody Formation by Thymus, Spleen, and Pronephros.- Fishes.- Amphibians.- Rosette-Cell Formation in Amphibian Thymus and Spleen and Fish Thymus, Spleen, and Pronephros.- Fishes.- Amphibians.- Thymus-Bone Marrow Interactions in the Leopard Frog.- Summary.- Acknowledgments.- References.- 2. Effect of Thymectomy on Immunological Responses in the Sheep.- Development of the Lymphoid Apparatus.- Prenatal Development.- Postnatal Development.- Development of Immunological Reactivity in the Lamb.- Production of Immunoglobulins in Fetal Lambs and in Newborn Lambs Deprived of Colostrum.- Effect of Fetal Thymectomy on the Development of the Lymphoid Apparatus in the Lamb.- Levels of Lymphocytes in the Blood and Lymph of Thymectomized Lambs.- Effect of Fetal Thymectomy on Immune Responses in the Lamb.- Autogenous Production of Immunoglobulins.- Humoral Antibody and Cellular Responses.- Transplantation and Hypersensitivity Reactions.- Lymphocyte Transfer Reaction in Thymectomized Lambs.- Discussion.- Acknowledgments.- References.- 3. Nature of the Responding Organism: Responders and Nonresponders.- Background.- Models of Ir Gene Function.- The PLL Gene.- The Ir-1 Gene.- Nonspecific T-Cell Activation.- Some Qualifications: Immune Response Genes and B Cells.- The T-Cell Receptor and the Ir Gene Product.- Summary.- References.- 4. The Intrathymic Environment.- The Intrathymic Environment.- Subcapsular Cortex.- Inner Cortex.- Medulla.- Perivascular Connective Tissue.- Control of Thymic Lymphocytopoiesis.- Summary.- References.- 5. A Note on Hassall's Corpuscles.- Microscopic Anatomy of Hassall's Corpuscles.- Hassall's Corpuscles and the Presumptive Blood-Thymus Barrier.- Do Hassall's Corpuscles Respond Morphologically in the Presence of Antigens?.- Hassall's Corpuscles in Thymuses Grown In Vitro.- Guinea Pigs.- Mice.- Some General Comments and Conclusions.- References.- 6. Cell Migration and the Thymus.- Movement of Thymocytes Inside the Thymus.- Emigration of Thymocytes.- Immigration of Cells into the Thymus.- Acknowledgments.- References.- 7. Ecology of Thymus Dependency.- Definition of the T Territory.- The Absent Population.- The Returning Population.- The Migrant Population.- Ecology of Thymus Dependency.- Morphological Changes After Antigen Stimulation.- Morphological Changes After Immunosuppression.- Brief Note on Phylogeny.- Concluding Remarks.- The Random Hypothesis.- The Ecotaxis Hypothesis.- References.- 8. Morphological Changes in the Thymus-Dependent Lymphoid System Associated with Pathological Conditions in Animals and Man: Their Functional Significance.- Selective Depletion of Lymphoid Tissue by Cyclophosphamide-Modulation of T Lymphocytes by B Lymphocytes.- Morphological Changes in the Thymus-Dependent Lymphoid Tissues in Some Infectious Diseases.- Granuloma Formation in Lymph Nodes.- Changes in the Thymus-Dependent Areas of the Spleen.- Summary.- References.- 9. Immunological Memory.- Adoptive Transfer of Memory.- Evidence for Memory in T and B Lymphocytes.- Origin and Evolution of T and B Memory Cells.- Requirement for Differentiation and Division of T and B Memory Cells in Collaborative Antibody Responses.- Relationship of T and B Memory Cells to Antigen-Binding Lymphocytes.- Life Span and Circulation Patterns of T and B Memory Cells.- Regulatory Influence of T Cells on Antibody Produced by B Cells.- Summary and Conclusions.- References.- 10. Effects of Adjuvants on Interactions of Different Cell Types in Immune Responses.- Effects of Adjuvants on Peritoneal Exudate Cells Containing Antigen.- Requirement of T Lymphocytes for Adjuvant Effects.- Discussion.- References.- 11. Cytotoxic Cells.- Editorial Comment.- Cytotoxic "B" Cells.- Evidence That Antibody Can Induce Lymphocyte-Mediated Cell Damage.- Antibody Against Lymphocytes.- Antibody Against Target Cells.- Evidence for Antibody Participating in Cytotoxicity Mediated by Immune Lymphocytes.- Nature of Lymphocytes Killing Sensitized Target Cells.- Assay of Effector-Cell Numbers.- Distribution of Effector Cells.- Differentiation from Antibody-Producing Cells and Their Precursors.- Dissociation of Effector Cells from Thymus-Processed Lymphocytes.- Evidence Against Macrophages Acting in the Chang-Cell System.- Thymus Dependency of the Overall Reaction.- Antibody-Induced Cytotoxicity by Lymphocytes in Perspective.- Conclusions.- References.- 12. Thymus Dependency of Rosette-Forming Cells.- Characteristics and Functions of RFC.- Immunized Mice.- Unimmunized Mice.- Are Rosette-Forming Cells T Cells9.- Immunized Mice.- Unimmunized Mice.- T-RFC Subpopulations.- T-Cell Markers.- Adult Thymectomy.- ALS In Vivo.- Thymic Hormones.- In Vitro Activity of Thymus Extracts.- In Vivo Activity of Thymic Extracts.- Presence of "Thymosin-Like" Activity in Normal Serum.- Interpretation.- T-RFC Receptors.- Clinical Applications of the Rosette Test.- Human RFC Detected with Sheep Cells.- Other Antigens.- Evaluation of Immunosuppressive Agents.- Thymic Hormones.- Summary.- References.- 13. Antigen-Binding Cells of the Thymus.- Nature of Antigen Receptors.- Antigen Receptors on Thymocytes.- Factors Influencing the Frequency of Thymic Antigen-Binding Cells.- Antigen Receptors on Thymus-Derived Lymphocytes.- Conclusions.- Acknowledgments.- References.- 14. Thymus Dependency and Chronic Antigenic Stimulation: Immunity to Parasitic Protozoans and Helminths.- Parasitic Protozoans.- Leishmania.- Trypanosoma.- Malaria Parasites (Plasmodium).- Helminths.- Trichinella.- Nippostrongylus.- Schistosoma.- General Comments and Conclusions.- Acknowledgments.- References.- 15. The Thymus and Immune Surveillance.- The Concept of Immune Surveillance.- Demonstration of Tumor Immunity.- Tumor Immunity in Relation to Immunological Status.- Thymus Dependency and Tumor Induction.- Chemical Carcinogenesis.- Virus-Induced and Spontaneous Tumors.- Spontaneous Tumors in Relation to Immune Deficiency.- Thymus Dependency During Tumor Growth.- Thymus-Dependent Responses Affecting Metastasis.- Nature of Thymus-Dependent Responses.- Activities of T Cells During Tumor Growth.- References.- 16. Thymus Independence.- Thymus-Independent "B" Lymphocytes.- Surface Properties and Distribution.- Physiological Properties.- Subclasses.- Role in Regulation of the Immune Response.- Role in Antibody-Mediated Cytotoxicity.- Features of T-Independent Antigens.- Features of the Antibody Response to T-Independent Antigens.- Immunoglobulin.- Memory.- Cell-Mediated Immunity.- Recognition by T Cells.- Mechanism of Antibody Production to T-Independent Antigens.- T-Independent Responses.- Relationship Between T-Independent and T-Dependent Antibody Responses.- Possible Thymus Influence on Antibody Production to T-Independent Antigens.- B-Cell Tolerance to T-Independent Antigens.- SIII.- Levan.- POL.- B-Cell Tolerance: Comparison Between T-Dependent and -Independent Antigens.- Significance of Thymus Independence.- References.- 17. Effect of Pregnancy on the Restoration of Immunological Responses in Neonatally Thymectomized Female Mice.- Summary of "The Pregnancy Experiment".- Further "Pregnancy Experiments".- Possible Future Investigations.- References.- 18. Thymus Hormones.- Diffusion Chamber Experiments.- The Pregnancy Experiment.- Thymic Extracts.- References.- 19. Thymic Humoral Factors.- Immunological Restoration of Thymectomized Animals by Thymus Implants Contained in Diffusion Chambers.- Thymus Preparations With Biological Activity.- References.- 20. Thymosin and Other Thymic Hormones: Their Nature and Roles in the Thymic Dependency of Immunological Phenomena.- Nature and Effects of Cell-Free Thymic Fractions.- Bioassays for Thymosin.- Purification and Biochemical Characterization of Thymosin.- Biological Studies With Thymosin in Normal and Thymectomized Mice.- Development of a Radioimmunoassay for Thymosin: Demonstration of Thymosin in Blood.- Maturation of the Immune System Under the Influence of Thymosin: Working Hypothesis.- Concluding Comments.- References.- 21. Some Clinical Implications of Thymus-Dependent Functions.- Development of the Human Thymus.- Immunological Effect of Thymectomy.- Immunodeficiency.- Immunodeficiency and Cancer.- The Thymus and Autoimmunity.- Clinical Tests of Thymus Function.- References.
「Nielsen BookData」 より