Excitatory amino acids and brain ischemia : pharmacological and clinical aspects : proceedings of the Biannual Capo Boi Conference on Neuroscinence, June 1989, Villasimius, Italy
著者
書誌事項
Excitatory amino acids and brain ischemia : pharmacological and clinical aspects : proceedings of the Biannual Capo Boi Conference on Neuroscinence, June 1989, Villasimius, Italy
（Advances in the biosciences, v. 78）
Pergamon Press, c1990
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内容説明・目次
内容説明
This volume focuses on new knowledge concerning the pathophysiological correlates of irreversible ischemic brain damage. Central to this theme is the well established finding that glutamate is lethal to brain cells following cerebral ischemia whilst, paradoxically, it is the most important neurotransmitter under normal physiological conditions. It has been shown that the neurotoxic effects of glutamate are due to an abusive stimulation of specific glutamate receptors leading to autophagic cell death. By manipulation of these receptors with allosteric and isosteric inhibitors it has proved possible to limit ischemic brain damage. This and other important considerations such as whether free radicals are involved, the role of nerve growth factor, and the protective effects of sphingolipids on glutamate-induced toxicity are addressed in this up-to-date collection from international research teams. The possible clinical applications of the findings and development of new remedies are also reviewed. This collection of papers will provide an indispensable overview for all those concerned with the investigation and treatment of ischemic brain damage.
目次
- Long-term synaptic modification by protein kinase C: regulation by activators, inhibitors and NMDA receptors, A Routtenberg. Extreme sensitivity to excitotoxic brain damage in youth and old age, J W Olney & C Ikonomi
- ou. Brain reactive processes triggered by permanent ischemic insult, A Gorio et al . Excitatory amino acid antagonists as neuroprotective agents, G N Woodruff & R Gill. E
- citatory amino acid release during in vitro and in vivo models of ischemia: are free radicals involved? D E Pellegrini-Giampietro et al . Enhanced sensitivity of "metabolotrophic" glutamate receptors after transient global ischemia in rat, F Nicoletti et al . Heterogenous distribution of excitatory amino acid receptor subtypes on rat spinal cord neurons in culture, O Arancio & A B MacDe
- mott. Treatment of brain ischemia: from preclinical pharmacology to clinical practice, R P Simon. Natural and semisynthetic sphingolipids protect neurons in culture from glutamate-induced toxicity, M Favaron et al . Exogenous GM1 ganglioside facilitates neurotransmitter recovery in the brain of developing rats after hypoxia, M Hadjiconstantinou et al . Cerebral ischemia and monosialoganglioside treatment: relationship with anti-neuronotoxic and pro-neuronotrophic effects, M S Seren et al . On the physiological role of NGF in CNS, G Vantini et al . Ischemia in post traumatic coma: implications for therapy, F Della Corte et al . Clinical trials in acute ischemic stroke, C Argentino et al . Subject index. 400 lit. refs. approx., 28 line drawings, 3 halftones
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