Protein structural analysis, folding and design
著者
書誌事項
Protein structural analysis, folding and design
Japan Scientific Societies Press , Elsevier, 1990
- : Japan
大学図書館所蔵 全29件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
内容説明・目次
内容説明
Our understanding of the structure-function relationship in proteins was revolutionized in the 1980's by the use of site-directed mutagenesis coupled with X-ray crystallography, which reveals the story of protein functions in their atomic resolution. This was still limited, however, to the hydrolytic enzymes hemoproteins such as myoglobin and hemoglobin. Our knowledge of protein-functions is also being increased through such computer-aided approaches as graphic design and molecular mechanics, although these approaches too are currently applicable for smaller proteins. From 1986 to 1988 a group of Japanese scientists pursued research on the structural analyses, folding and design of various types of proteins including cytochrome P450, ferredoxins, hemoglobin, erbutoxin, neurotoxins, tryptophan synthase, thermophile isopropylmaleate dehydrogenase, fatty acid synthetase, ion-channel proteins and abnormal hemoglobins. Their findings are summarized in this volume, providing data on the capability and potential of site-directed mutagenesis, mutations in nature, and computer-aided predictions for more complicated proteins.
目次
Preface. I. Protein Structural Analysis and Folding . Protein Confirmation in Terms of Conformational Energy Analysis (H. Wako). Some Remarks on Protein Folding (N. Saito, K. Yura and Y. Fukuda). Postsynaptic Snake Neurotoxin: A Flexible Protein That Binds to the Acetylcholine Receptor (T. Endo and N. Tamiya). Characterization of the Folding Intermediates of Globular Proteins (S. Sugai, K. Kuwajima and K. Nitta). Physical and Biological Stability of Globular Proteins (S. Kidokoro, Y. Miki and A. Wada). Refined Structure of a [2Fe-2S] Ferredoxin I from Aphanothece sacrum: Intramolecular Interaction and Structural Organization (T. Tsukihara, K. Fukuyama, H. Matsubara and Y. Katsube). II. Higher-Order Structure of Protein Systems . Compound Function and Higher-Order Structure of Animal Fatty Acid Synthetase (H. Kyushiki, T. Kitamoto and A. Ikai). Denaturation of Membrane Proteins: Ion Channel, Calcium-ATPase and Baacteriorhodopsin (S. Mitaku, F. Kukita and M. Kasai). Clusterization of Proteins in Solution under Velocity Gradient of Solvent Flow (F. Hirakawa, S. Yoshino, M. Sogami and N. Imai). III. Mutation and Structural Design of Proteins. Molecular Physiology and Pathology of Hemoglobin M (M. Nagai and Y. Yoneyama). The Role of the Distal Residues of Haemoglobin (J. Tame). Manipulation of Hemoglobin Function by Protein Engineering (K. Imai, K. Ishimori, K. Fushitani, G. Miyazaki, T. Kitagawa, Y. Wada, H. Morimoto, I. Morishima, D. Shih, J. Tame and K. Nagai). Site-Directed Mutagenesis of Rat Liver Cytochrome P-450 d (M. Hatano, T. Shimizu, O. Ito, K. Hirano, H. Furuya, A.J. Md. Sadeque, Y. Fujii-Kuriyama, R. Raag and T.L. Poulos). Conformational Stability of Mutant Tryptophan Synthase alpha-Subunit (K. Yutani and K. Ogasawara). Subject Index. Imprint: Amsterdam/JSSP
「Nielsen BookData」 より