Microbial membrane transport systems : proceedings of a Royal Society discussion meeting held on 22 and 23 February 1989

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Bibliographic Information

Microbial membrane transport systems : proceedings of a Royal Society discussion meeting held on 22 and 23 February 1989

organized and edited by Sir Hans Kornberg, and P. J. F. Henderson

The Royal Society, 1990

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Note

"First published in Philosophical transactions of the Royal Society of London, series B, volume 326(no.l236), pages 339-514"-- T.P. verso

Description and Table of Contents

Description

This book contains papers presented at a Royal Society Discussion Meeting held in February 1989, 50 years after C.J. Deere and his colleagues described a mutant of "Escherichia coli" that, unlike its wild-type cousins, could not ferment factose. The full significance of this observation was not realized until some time later, most profoundly by the combination of biochemical and genetic investigations of workers at the Pasteur Institute in the 1950s; they describe the inducible proteins that selectively effect the uptake of substances into micro-organisms, "permeases". The Discussion Meeting sought to bring workers on a wide variety of systems and materials together to compare, to seek for common themes, to speculate and even to plan future approaches together. There are several detailed structural studies, from the atomic structure of periplasmic binding and the high-affinity active transport system in bacteria to the structures and homologies of carbohydrate: phosphotransferase proteins. The mechanisms of sodium and fructose transport are discussed, along with homologous sugar transport proteins, the melibiose Na+ symporter and the "Lac" permease of "Escherichia coli". There are also articles on the structure of bacteriorhodopsin, the molecular analysis of an ATP-dependent anion pump, the structural aspects of proton-pumping ATPases and periplasmic binding protein-dependent transport systems. The bacterial kdp K+ ATPase is discussed in detail and there is a review of the resolution and reconstitution of anion exchange reactions. With the growing realization that microbial transport proteins exhibit homologies to various degrees not only among themselves, but also to membrane proteins of eukaryotic cells, this book represents a timely review of the current situation.

Table of Contents

  • Atomic structures of periplasmic binding proteins and the high-affinity active transport systems in bacteria, F.A.Quiocho
  • periplasmic binding protein-dependent transport systems - the membrane-associated components, C.F.Higgins et al
  • structural aspects of proton-pumping ATPases, J.E.Walker et al
  • the structure of bacteriorhodopsin and its relevance to the visual opsins and other seven-helix G-protein coupled receptors, R.Henderson and G.F.X.Schertier
  • homologous sugar transport proteins in "Escherichia coli" and their relative in both prokaryotes and eukaryotes, P.J.F.Henderson and M.C.J.Maiden
  • the melibiose/NA+ symporter of "Escherichia coli" - kinetic and molecular properties, T.Pourcher et al
  • "Lac" permease of "Escherichia coli" - on the path of the proton, H.R.Kaback
  • resolution and reconstitution of anion exchange reactions, P.C.Maloney
  • molecular analysis of an ATP-depedent anion pump, B.P.Rosen
  • mechanisms of sodium transport in bacteria, P.Dimroth
  • the bacterial kdp K+ ATPase and its relation to other transport ATPases, such as the Na+/K and Ca2+-ATPases in higher organisms, W.Epstein et al
  • structures and homologies of carbohydrate - phosphotransferase (PTS) proteins, J.W.Lengeler et al
  • fructose transport by "Escherichia coli", H.L.Kornberg.

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