Chromosomal aberrations : basic and applied aspects
著者
書誌事項
Chromosomal aberrations : basic and applied aspects
Springer-Verlag, c1990
- : gw
- : us
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注記
Includes index
内容説明・目次
内容説明
Chromosomal aberrations represent an important type of possible mutation. Basic aspects of chromosomal aberrations such as their origin and the importance of genetic repair are addressed in this text. Their practical applications, such as the use of chromosomes in genetic toxicology, are also discussed. The following topics are tackled: computerized analyses of chromosomes; DNA repair; induction of chromosomal aberrations with restriction endonucleases; chromosomes and cancer; adaptive responses to low doses of mutagens; biological dosimetry; chromosomal aberrations in meiosis; formation of micronuclei and their importance in genetic toxicology, and chromosomal aberrations as indicators of mutagenic activities.
目次
Quantitative Detection of Chromosome Structures by Computerized Microphotometric Scanning.- Heterogeneity of DNA Repair in Relation to Chromatin Structure.- The Poly-ADP-Ribosylation System of Higher Eukaryotes: How Can It Do What?.- DNA Lesions, DNA Repair, and Chromosomal Aberrations.- Is It Misrepair or Lack of Repair Which Kills Cells Irradiated in G2?.- Inhibitors of DNA Topoisomerases and Chromosome Aberrations.- Restriction Endonuclease- and Radiation-Induced DNA Double-Strand Breaks and Chromosomal Aberrations: Similarities and Differences.- The Use of Restriction Endonucleases to Study the Mechanisms of Chromosome Damage.- Induction of Chromosomal Aberrations by the Restriction Endonuclease Alul in Chinese Hamster Ovary (CHO) Cells: Influence of Glycerol on Aberration Frequencies.- Patterns of Chromosome Variations in Neoplasia.- Tumorigenesis and Tumor Response: View from the (Prematurely Condensed) Chromosomes.- Detection of Cancer-Prone Individuals Using Cytogenetic Response to X-Rays.- Human Disorders with Increased Spontaneous and Induced Chromosomal Instability.- Possible Causes of Variability of the Adaptive Response in Human Lymphocytes.- Adaptation of Human Lymphocytes to Radiation or Chemical Mutagens: Differences in Cytogenetic Repair.- Radio-Adaptive Response: A Novel Chromosomal Response in Chinese Hamster Cells in Vitro.- On Adaptive Response of Plant Meristem Cells in Vivo - Protection Against Induction of Chromatid Aberrations.- Chromosome Aberrations in A-Bomb Survivors, Hirsohima and Nagasaki.- Biological Dosimetry of Absorbed Radiation Dose: Considerations of Low-Level Radiations.- Use of Micronuclei in Biological Dosimetry of Absorbed Radiation Dose.- Biological Dosimetry After Radiation Accidents.- Dose Estimates and the Fate of Chromosomal Aberrations in Cesium-137 Exposed Individuals in the Goiania Radiation Accident.- Cytogenetic Studies in Male Germ Cells, Their Relevance for the Prediction of Heritable Effects and Their Role in Screening Protocols.- Use of in Vivo Micronucleus Tests with Mammalian Cells for Clastogenicity and Carcinogenicity Studies.- In Vitro Chromosomal Aberration Test - Current Status.- Clastogenesis in Vitro Under Extreme Culture Conditions.- Life-Style and Genetic Factors that Determine the Susceptibility to the Production of Chromosome Damage.
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