Protease inhibitors : proceedings of the Second International Conference on Fibrinolysis, Hamamatsu, Japan, 26 August 1989

Bibliographic Information

Protease inhibitors : proceedings of the Second International Conference on Fibrinolysis, Hamamatsu, Japan, 26 August 1989

editors, A. Takada, M.M. Samama, D. Collen

(International congress series, no. 873)

Excerpta Medica, 1990

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Includes index

Description and Table of Contents

Description

This book containing the proceedings of the Second International Conference on Fibrinolysis deals with current progress in research of protease inhibitors related to fibrinolysis. It will be of interest not only to researchers and clinicians in the field of thrombosis and hemostasis, but also biochemistry, physiology, pathology, clinical chemistry and clinicians in hematology in general.

Table of Contents

Content headings: Preface. Acknowledgements. Overview. STRUCTURE AND FUNCTIONS OF PLASMINOGEN ACTIVATOR INHIBITORS. The cell and molecular biology of type 1 plasminogen activator inhibitor (D.J. Loskutoff). Plasminogen activator inhibitor type 2: Biochemical and biological aspects (E.K.O. Kruithof). Structure-functional analysis of plasminogen activator inhibitors type 1 and 2 using in vitro mutagenesis (T. Ny, D. Lawrence, P. Mikus, L. Strandberg and B. Astedt). Plasminogen activator inhibitor (PAI-1): Interaction with vitronectin and plasminogen activators (B. Wiman, T.L. Lindahl and O. Sigurdardottir). ASSAYS AND ACTIVITIES OF PLASMINOGEN ACTIVATOR INHIBITORS .Measurements of the concentration of free plasminogen activator inhibitor 1 and its complex with tissue plasminogen activator in human plasma (A. Takada, T. Urano and Y. Takada). Comparison of two techniques for the determination of plasminogen activator inhibitor (PAI) in plasma (C. Delfour, P.van Dreden, J. Conard and M. Samama). The influence of fibrin on the kinetics of inhibition of plasminogen activators by their specific inhibitors (S. Thorsen, M. Roder, M. Philips, E. Suenson, I. Lecander and B. Astedt). ANTITHROMBIN III, HEPARIN COFACTOR II, PROTEIN C INHIBITOR AND alpha 2 PLASMIN INHIBITOR . Effects of zinc and calcium ions on the neutralization by histidine-rich glycoprotein of the herapin-dependent activities of plasma proteinase inhibitors (T. Koide and Y. Kazama). Protein C inhibitor: Structure and complex formation with activated protein C (K. Susuki). Regulation of the protein C pathway by plasma protease inhibitors (M.J. Heeb, F. Espa#a, M. Geiger and J.F. Griffin). Molecular genetics of alpha 2 plasmin inhibitor (N. Aoki). CLINICAL RELEVANCE OF PLASMA PROTEASE INHIBITORS . Plasminogen activator inhibitor-1 (PAI-1). An inhibitor of functional expedience (P.J. Gaffney, P.S. Gascoine, J.B. Pring and J.A. Paramo). Variations of plasma levels of free PAI-1, t-PA-PAI-1 complex and t-PA in human males and females at various ages (Y. Takada, T.Urano and A. Takada). Plaminogen activator inhibitor 1 and athero-thrombosis (I. Juhan-Vague and M.C. Alessi). Monitoring the therapy with antithrombin III concentrates in hereditary and acquired antithrombin III deficiency (G. Pindur, B. Rodemer, E. Wenzel, C. Miyashita, M. Heiden and M. Kohler). Clinical rheological and haemostaseological aspects of the dysfibrinogenemia (E. Wenzel, U.T. bauer and R. Kotitschke). Analysis of coagulation/fibrinolysis abnormalities in preeclamptic patients (T. Kobayashi, T. Terao, M. Maki, K. Gotoh, M. Murata, T. Ikenoue, H. Samejima, H. Iwasaki, J. Shibata, M. Nakabayashi, M. Muraoka, Y. Takeda, S. Sakamoto, N. Imai and H. Oda). INTRACELLULAR PROTEASE INHIBITORS, SYNTHETIC PROTEASE INHIBITORS AND PLANT PROTEASE INHIBITORS : Intracellular protease and its inhibitor - Structural implications interaction of calcium dependent protease and its inhibitor (H. Kawasaki, Y. Emori and K. Suzuki).

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