Idiosyncratic adverse drug reactions : impact on drug development and clinical use after marketing : proceedings of the satellite symposium to the IV World Conference on Clinical Pharmacology and Therapeutics, Mannheim-Heidelberg, 29-30 July 1989
著者
書誌事項
Idiosyncratic adverse drug reactions : impact on drug development and clinical use after marketing : proceedings of the satellite symposium to the IV World Conference on Clinical Pharmacology and Therapeutics, Mannheim-Heidelberg, 29-30 July 1989
（International congress series, no. 878）
Excerpta Medica, 1990
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注記
Includes index
内容説明・目次
目次
Idiosyncratic Adverse Drug Reactions: Challenges to Clinical Pharmacologists (C.A. Naranjo, B.M. Ghajar and K.L. Lanctot). The implications of Idiosyncratic Reactions for New Drug Development (L. Lasagne). Important Idiosyncratic Drug Reactions (G.R. Venning). Discussion. Panel Discussion: Idiosyncratic Reactions: The Role of Clinical Trials in Detecting, Predicting or Defining Limits of Frequency. (Chairman: L. Lasagne). (M. Auriche, J. Idanpaan-Heikkila, N. Shear, M.D.B. Stephens, and B.-E. Wiholm). Clozapine Induced Blood Disorders in 1975-1989 in Finland: A Review of a Drug From Withdrawal to Re-approval With Restrictions (J. Idanpaan-Heikkila). Discussion - Drug Discontinuations Due to Idiosyncratic Reactions: Regulatory Viewpoint. Drug Discontinuations Due to Idiosyncratic Reactions: Industry Viewpoint (G. Lewandowski). Discussion - Drug Discontinuations Due to Idiosyncratic Reactions: Industry Viewpoint. Panel Discussion: The Impact of Drug Discontinuations: Medical, Social, Pharmaceutical, Legal, etc. (Chairman: C.A. Naranjo) (J.K. Jones, L. Lasagna, G. Lewandowski, S. Spielberg, M.D.B. Stephens and B.E. Wiholm). Clinical Manifestations of Idiosyncratic Reactions - Introductory Remarks. (J.K. Jones). The Liver as a Target Organ For Idiosyncratic Reactions (B. Begaud). The Skin as a Target Organ For Adverse Drug Reactions (N.S. Shear). The Bone Marrow as the Target for Idiosyncratic Reactions. Discussion: The Bone Marrow as the Target for Idiosyncratic Reactions. Other Important Sites For Idiosyncratic Reactions or Reflections on the Diversity of Reactions (M.D.B. Stephens). Discussion - Other Important Sites For Idiosyncratic Reactions of Reflections on the Diversity of Reactions. Pathogens and Pharmacogenetics of Idiosyncratic Hypersensitivity. Adverse Drug Reactions (S. Spielberg). Genetic mechanisms of Idiosyncratic Drug Reactions (W. Kalow). Epidemiologic Approaches to Idiosyncratic Reactions (J.K. Jones). The Bayesian Differential of Idiosyncratic Reactions to New Drugs: Neutropenia and Antiarrhythmic Agents (C.A. Naranjo, K.L. Lanctot and D.A. Lane). Panel Discussion: International Collaboration for Studying Idiosyncratic Drug Reactions. (Chairperson: J.K. Jones). (B. Begaud, W. Kalow, L. Lasagne, C.A. Naranjo, S. Spielberg and B.-E. Wiholm). Concluding Remarks (C.A. Naranjo and J.K. Jones).
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