Testing and evaluation of drugs of abuse

著者

書誌事項

Testing and evaluation of drugs of abuse

editors, Martin W. Adler, Alan Cowan

（Modern methods in pharmacology, v. 6）

Wiley-Liss, c1990

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注記

Includes bibliographical references

内容説明・目次

内容説明

This volume focuses on recent methodological advances and assesses the relative strengths and weaknesses of various research methods in current use. The book describes how critical biological information on the major drugs of abuse is obtained in both laboratory and clinical settings, emphasizing how the apparently irreconcilable spheres of controlled laboratory experimentation and illicit drug use in the real world must be brought together so that discoveries made in one realm can effectively guide the direction of inquiry for the other. Everything from radioligand binding assays in the laboratory to heroin/cocaine "speedballing" on the street receives coverage. By taking a critical, analytic approach to the methodologies of modern drug research, the text provides not only a report of the latest findings, but also a framework for understanding the biochemical basis of addiction and planning strategies for future drug research and treatment programs.

目次

  • Radioligand Binding
  • Use of Isolated Tissue Preparations to Evaluate Opioid Drugs of Abuse
  • Recent Approaches in the Testing of Analgesics in Animals
  • Methods for the Study of Tolerance
  • Assessment of Physical Dependence Techniques for the Evaluation of Abused Drugs
  • Approaches to the Characterization of Drug Effects on Locomotor Activity in Rodents
  • Drugs of Abuse and Body Temperature
  • Drugs of Abuse: In Vivo Measures of CNS Excitability
  • Brain-Stimulation Reward: A Model for Drug-Induced Euphoria
  • Drugs of Abuse and the Fetus and Neonate: Testing and Evaluation in Animals
  • Drug Interactions in Humans Related to Drug Abuse and Its Treatment.

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