Biological oxidation systems

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書誌事項

Biological oxidation systems

edited by C. Channa Reddy, Gordon A. Hamilton, K.M. Madyastha

Academic Press, c1990

  • v. 1
  • v. 2

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注記

"Proceedings of the Symposium on Biological Oxidation Systems, held in Bangalore, India on Oct. 22-26, 1989 and sponsored by the National Science Foundation"--pref

Includes bibliographical references and indexes

内容説明・目次

巻冊次

v. 1 ISBN 9780125845519

内容説明

Biological Oxidation Systems, Volume I is a collection of papers presented at the 1989 Bangalore Symposium on Oxygen Systems. This symposium covers various research studies on the essential roles, and the dangers of dioxygen reactions in biology. This volume is organized into five parts encompassing 32 chapters, and starts with an overview of the biological oxidation mechanisms involving oxygen and reduced oxygen derivatives. Parts I and II deal with the catalytic role of cytochrome P-450 and oxidase and oxygenase containing a flavin or pteridine enzymes in several biological oxidation reactions. These parts examine the biochemical aspects, reaction kinetics, and reaction mechanisms of such reactions. Parts III and IV describe first the structure function and properties of copper-containing oxidases and oxygenases. These parts also discuss the role of nonheme iron-containing and other oxygenases in the indole metabolism. Part V focuses on the role of peroxidase enzymes in cell protection and metabolism. This book will prove useful to biologists, enzyme scientists, and researchers.

目次

  • Contents Volume 2 Foreword Preface Sponsors Overview: Mechanisms of Biological Oxidations Mechanisms of Biological Oxidation Reactions Involving Oxygen and Reduced Oxygen Derivatives I. Cytochrome P-450 Catalyzed Reactions The Cytochrome P-450 Superfamily: Impact on Biology and Medicine Transcriptional Regulation of Cytochrome P-450b/e Gene Expression in Rat Liver Oxidation Reactions Catalyzed by Cytochrome P-450 Enzymes Cellular Responses To Oxidative Stress Abberations in Cytochrome P-450 and Mixed Function Oxidase System Preferential Induction of Biological Oxidation Systems in Alkaloid Metabolism of Plant Tissues Cultures Subjected to Fungal Elicitation (+)-Pulegone Mediated Hepatotoxicity in Rat
  • Role of Microsomal Cytochrome P-450 Cytochrome P-450 Catalyzed Reactions in Brain Microsomal Cytochrome P-450 Mediated N-Oxygenation of Amino Azaheterocycles Presence of Phenobarbital and 3-Methylcholanthrene Inducible Forms of Cytochrome P-450 in Rat Brain Recriprocal Post-Translational Regulation of Chick Kidney Mitochondrial 1a- and 24R-Hydroxylase of 25-Hydroxyvitamin D3 Cytoprotective Mechanisms that Offset the Potential Augmentation of Phenobarbital-Induced 02-* Generation During Quinone Recylcling II. Oxidases and Oxygenases Containing a Flavin/Pteridine Studies on the Mechanism of the Uncoupled Reaction Catalyzed by Rat Liver Phenylalanine Hydroxylase Why is the Cofactor for the Tetrahydrobiopterin Dependent Monooxygenases not a Dihydroflavin? Biochemical Aspects of Molybdopterin The Kinetics and Regulation of Aromatic Amino Acid Hydroxylases: The Effect of Cofactor Structure The Mechanism of Oxygen Activation by Flavoprotein Monooxygenase III. Copper-Containing Oxidases and Oxygenases Copper Proteins: A Review of the Different Classes of Copper Proteins and an In-Depth Investigation of the Active Copper Sites in Dopamine ss-Hydroxylase Structure Function Studies of Dopamine ss-Hydroxylase Novel Oxidation Chemistry of Catecholamine Derivatives and Related Compounds IV. Nonheme Iron-Containing and Other Oxygenases Methane Monooxygenase: A Novel Biological Catalyst 0for Hydrocarbon Oxidations Ozone-Induced Alterations in Quantity and Activity of Rubisco: Implications for Foliar Senescence Three Isozymes of Catechol 1,2-Dioxygenase (Procatechase) from ?seudomonas Arvilla C1 The Role of Oxygenase in the Metabolism of Indole V. Peroxidases in Cell Protection and Metabolism Lignin-Degrading Peroxidases from Phanerochaete Chrysosporium Oxidation of Environmental Pollutants by Lignin Peroxidases from White Rot Fungi Selenoenzymes and Seleno-tRNAs Selenium-Dependent Glutathione Peroxidase: Expression in Selenium Deficiency Resonance Raman Spectroscopic Characterization of Horseradish Peroxidase Intermediates Gastric Peroxidase and Its Role in Cellular Control of Gastric Acid Secretion The Role of Glutathione Transferases in the Cellular Resistance to Electrophilic Compounds Produced by Biological Oxidations Superoxide Dismutase Isozymes and Toxicity of Environmental Xenobiotics Author Index Key Word Index
巻冊次

v. 2 ISBN 9780125845526

内容説明

Biological Oxidation Systems, Volume II discusses the various antioxidants and antioxidant enzymes that play significant roles in protecting cells from deleterious reactions between their structural/functional components and the free radicals. This book examines the myriad chemical reactions of a cell's metabolic activity that produce a variety of free radicals. Comprised of three parts encompassing 35 chapters, this volume starts with an overview of the metabolism of xenobiotics during arachidonic acid metabolism. This book then discusses the various causes of human cancers and diseases, which include exposure to environmental chemicals and other toxicants. This text considers the dietary habits and nutritional factors that play an important role in the causation and development of several human cancers, including cancer of the breast, colon, prostate, and other organs. Other chapters discuss the toxic effects of several xenobiotics that involve free-radical mechanisms. Biochemists, biophysicists, microbiologists, organic chemists, food chemists, and medical scientists will find this book extremely useful.

目次

Sponsors Foreword Preface VI. Oxidation Mechanisms in Carcinogenesis Oxidations Catalyzed by Prostaglandin H Synthase Oxidation Reactions by Endoperoxide Synthase Molecular Mechanisms for the Peroxidase Catalyzed Activation of Arylamine Carcinogens to Cytotoxic Metabolites Inhibitors of Carcinogenesis The Role of Iron in Asbestos-Catalyzed Damage to Lipids and DNA Selective Enhancement of Free Radicals by cis-Unsaturated Fatty Acids in Tumor Cells as a Strategy to Kill Tumor Cells In Vitro and In Vivo Inhibition of Binding of Aflatoxin ?1 to Renal DNA by Dehydroepiandrosterone VII. Enzymes in Prostaglandin and Leukotriene Metabolism Prostaglandin H Synthase Peroxide Tone and Its Consequences Involvement of Glutathione Peroxidases in Prostaglandin Biosynthesis Non-Cyclooxygenase Prostaglandin Biosynthesis: Formation of PGA3 Isomers Via an Allene Oxide Non-Cyclooxygenase Oxidative Formation of a Series of Novel Prostaglandins: Ramifications for the Measurement of Eicosanoids in Biological Fluids Lipoxins: Bioactive Eicosanoids Generated by Lipoxygenase Interactions Novel Hepoxilin Glutathione Conjugates with Biological Activity Optically Pure Allylic Hydroperoxides: Mechanisms for Hydroperoxide Rearrangements Arachidonate 12-Lipoxygenases The Unique Characteristics of the Purified 5-Lipoxygenase from Potato Tubers and the Proposed Mechanism of Formation of Leukotrienes and Lipoxins Arachidonic Acid Oxidation and Platelet Function Role of Eicosanoids of the Lipoxygenase Pathway in Vertebrate Reproduction Endogenous Formation of Leukotriene C4 In Vivo and Characterization of Novel Metabolites Formed In Vitro and In Vivo VIII. Lipid Peroxidation and Other Nonenzymatic Reactions of Oxygen Vitamin E In Vivo Interaction of Glutathione and a-Tocopherol in the Inhibition of Lipid Peroxidation in Rat Liver Microsomes Glutathione and Vitamin E and the Control of Lipid Peroxidation of Rat Liver Nuclei Mechanisms of Vitamin E Control of Lipid Peroxidation: Regeneration, Synergism, Asymmetry, Migration, and Metal Chelation Vanadium as a Biological Hydrogen-Abstractive Agent Constitutive and Inducible Repair Systems in Oxidative Stress Oxidative Damage to Proteins Mediated by Singlet Oxygen Molecular Mechanisms of Oxidative Cell Damage Oxidative Myocardial Injury and Cardiac-Derived Experimental Systems Mitochondrial Generation of Hydroxyl Radical During Reperfusion of Ischemic Myocardium Role of Lipid Peroxides in Aging Hepatocellular Regeneration as a Determinant of Halomethane Hepatotoxicity Structure Activity Correlations of 1,4-Dihydropyridines as Reducing Agents Modulation of Tubulin Tyrosinolation in Human Neutrophils by the NADPH Oxidase-Mediated Respiratory Burst Isolation and Characterization of a Mammalian Hydroxyacid-Oxoacid Transhydrogenase Author Index Key Word Index Symposium Delegates

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