Cyclic nucleotide phosphodiesterases : structure, regulation and drug action
著者
書誌事項
Cyclic nucleotide phosphodiesterases : structure, regulation and drug action
（Wiley series on molecular pharmacology of cell regulation, v. 2）
Wiley, c1990
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注記
"A Wiley-Interscience publication."
内容説明・目次
内容説明
Molecular Pharmacology of Cell Regulation Series Editor: M. D. Houslay This important Series provides topical, in depth and authoritative reviews on all aspects of the molecular mechanisms of cell regulatory processes. It attempts to unravel the molecular structures, properties and functions of systems which provide putative targets for the next generation of drugs. It will, therefore, be of major interest to biochemists, pharmacologists, molecular pathologists, endocrinologists, cell biologists and research clinicians working on the fundamental description of how cells regulate their own and each others activity, on the development of novel therapeutic agents and on analyses of pathological changes and genetic lesions. Volume 2 Cyclic Nucleotide Phosphodiesterases: Structure, Regulation and Drug Action Edited by J. Beavo Department of Pharmacology, University of Washington, USA and M. D. Houslay Institute of Biochemistry, University of Glasgow, UK Cyclic nucleotide phosphodiesterases play a vital role in cell regulation as the enzymes which mediate the degradation of important second messenger molecules.
For the first time, this book brings together the latest available information and opinion on the different species of phosphodiesterases and their isoenzymes. It includes sections on their identification, purification, structure and properties; the organisation of their encoding genes; regulation of phosphodiesterase activity in visual transduction, hormonal activation, cellular differentiation and pathological states; and the mode of action of selective inhibitors of phosphodiesterases and their therapeutic use in conditions such as congestive heart failure.
目次
Partial table of contents: SPECIFIC FORMS OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES. Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterases (J. Wang, et al.). Cyclic GMP-Inhibited Cyclic Nucleotide Phosphodiesterases (V. Manganiello, et al.). Cyclic CMP-Specific Phosphodiesterase Activity (R. Newton, et al.). ANALYSES OF PHOSPHODIESTERASE FORMS AND THEIR FUNCTION IN SPECIFIC CELLULAR SYSTEMS. Phosphodiesterases in Visual Transduction by Rods and Cones (P. Gillespie). STRUCTURAL AND FUNCTIONAL ANALYSES OF PHOSPHODIESTERASES USING MOLECULAR BIOLOGICAL TECHNIQUES. Molecular Genetics of the Cyclic Nucleotide Phosphodiesterases (R. Davis). Structure and Function of the Rolipram-Sensitive, Low Km Cyclic AMP Phosphodiesterases: A Family of Highly Related Enzymes (M. Conti & J. Swinnen). DEVELOPMENT OF SELECTIVE INHIBITORS OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES AS THERAPEUTIC AGENTS. Cardiac Phosphodiesterases and the Functional Effects of Selective Inhibition (M. Reeves & P. Englund). Second Generation Phosphodiesterase Inhibitors: Structure-Activity Relationships and Receptor Models (P. Erhardt). Abbreviations. Index.
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