Drug safety in pregnancy
著者
書誌事項
Drug safety in pregnancy
Elsevier , Sole distributor for the USA and Canada, Elsevier Science Pub. Co., 1990
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注記
Includes bibliographical references
Includes index
内容説明・目次
内容説明
This book combines the perspectives of clinical and laboratory medicine so as to present critically considered and practical information to the clinician concerning drug-induced injury to the human embryo and fetus. The information that has been included has been thoroughly and independently evaluated by the authors at source. Animal and pharmacokinetic data have been used when their relevance to the human situation is direct, or where they demonstrate important principles. Classical teratology syndromes, such as those caused by thalidomide or diethystilboestrol have been examined in some detail, even though the use of these agents in pregnancy no longer reflects contemporary practice. This has been done because they add an understanding of clinical teratology. "Drug Safety in Pregnancy" can be regarded as a companion book to Meyler's Side Effects of Drugs, and to the Side Effects of Drugs Annuals, and care has been taken to include material contained in recent editions of those volumes. The book provides a comprehensive and critical data base for any clinician, pharmacologist or research worker concerned with the safe use of medicines in the pregnant woman.
目次
Preface. Fontispiece. How to use this book. 1. Thalidomide. 2. Amphetamines. 3. Tricyclic antidepressants. 4. Lithium. 5. Ethanol. 6. Cigarette smoking. 7. Caffeine. 8. Drugs of abuse. 9. Neuroleptic agents. 10. Benzodiazepines. 11. Anticonvulsants. 12. Opioid analgesics. 13. Nonsteroidal anti-inflammatory agents, and paracetamol. 14. Anaesthetic agents (general and local anaesthetics). 15. Sympathomimetic agents. 16. Antihypertensive drugs, and beta adrenoreceptor blocking agents. 17. Diuretics. 18. Penicillamine and gold. 19. Antibiotics and chemotherapeutic agents. 20. Drugs used in tuberculosis. 21. Antimalarials. 22. Vaccines. 23. Anticoagulants. 24. Haematinics. 25. Drugs acting on the gastrointestinal tract. 26. Anti-emetic agents. 27. Vitamins and the retinoids. 28. Corticosteroids. 29. Hormonal contraceptives. 30. Diethylstilboestrol, and related agents affecting fetal sex hormone development. 31. Spermicidal agents. 32. Thyroid and antithyroid drugs. 33. Oral hypoglycaemic agents. 34. Prostaglandins. 35. Cytotoxic and immunosuppresive agents. Appendices: I. Abnormal fetal genitourinary system development associated with drugs. II. Drugs associated with polydactyly and syndactyly. III. Reported association of congenital abnormalities of bones and intra-uterine drug exposure. IV. Limb reduction deformities associated with drug exposure in utero. V. Drug related anencephaly, exencephaly and spina bifida in humans. VI. Human congenital cardiac defects that have been associated with drug exposure in utero. VII. Drugs associated with congenital hearing loss and/or microtia. VIII. Drugs associated with congenital ocular defects. IX. Drugs associated with oral clefts. X. X-irradiation. XI. Behavioural teratology. XII. The kinetics of drugs during pregnancy - general principles. XIII. Evolution and prediction of drug safety in pregnancy. XIV. Attempted suicide with drugs in pregnancy. Index of drugs. Index of side effects.
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