Selective serotonin re-uptake inhibitors : the clinical use of citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline

書誌事項

Selective serotonin re-uptake inhibitors : the clinical use of citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline

J. P. Feighner and W. F. Boyer

(Perspectives in psychiatry, v. 1)

Wiley, c1991

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Over the past ten years, researchers have had the opportunity, at the Feighner Research Institute, to work with paroxetine, fluoxetine and other selective serotonin re-uptake inhibitors. They maintain that these drugs represent a significant addition in psychiatry because of their relative lack of side-effects and broad range of potential clinical indications. Indeed, their widespread and increasing use in the United States and other countries underlines this importance. This book reflects the state of the art in terms of the clinical issues surrounding these medications. The first chapter of the book reviews the evidence that points to the effects of these drugs on serotonergic function and the central role of serotonin in many psychiatric disorders, while the following chapter reviews the pharmacology of the selective serotonin re-uptake inhibitors. The remaining chapters contain reviews of clinical trials of the selective serotonin re-uptake inhibitors in many of the conditions previously mentioned, concluding with a chapter on important clinical issues in the use of these agents. This book is aimed at all those who take care of depressed patients, but especially at residents and clinicians in psychiatry and general medicine. Clinicians are confronted daily with human suffering and require knowledge of what is both safe and effective for their patients. This is a different stance from that of the pure scientist, who accepts nothing as fact until replicated experimental evidence is available. Hence the purpose of this book is to review the available evidence from a clinical standpoint.

目次

  • The neuropharmacology of serotonin in the central nervous system, C.A.Marsden
  • the comparative pharmacological properties of selective serotonin re-uptake inhibitors in animals, A.M.Johnson
  • the serotonin hypothesis - necessary but not sufficient, W.F.Boyer and J.P.Feighner
  • pharmacokinetics and drug interactions, W.F.Boyer and J.P.Feighner
  • the efficacy of selective serotonin re-uptake inhibitors in depression, W.F.Boyer and J.P.Feighner
  • the efficacy of selective serotonin re-uptake inhibitors in anxiety and obsessive-compulsive disorder, W.F.Boyer et al
  • other potential indications for selective serotonin re-uptake inhibitors, W.F.Boyer and J.P.Feighner
  • side-effects of the selective serotonin re-uptake inhibitors, W.F.Boyer and J.P.Feighner
  • clinical use of the selective serotonin re-uptake inhibitors, W.F.Boyer et al.

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