Chirality and biological activity : proceedings of an international symposium held at Tubingen, Federal Republic of Germany, April 5-8, 1988

著者

    • Frank, Hartmut
    • Holmstedt, Bo
    • Testa, Bernard
    • Tübingen Symposium on Chirality and Biological Activity (1st : 1988)

書誌事項

Chirality and biological activity : proceedings of an international symposium held at Tubingen, Federal Republic of Germany, April 5-8, 1988

editors, Bo Holmstedt, Hartmut Frank, Bernard Testa

A.R. Liss, c1990

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注記

Papers presented at the First Tübingen Symposium on Chirality and Biological Activity, held April 5-8, 1988

Includes bibliographical references

内容説明・目次

内容説明

Reporting on the latest advances in molecular asymmetry, "Chirality and Biological Activity" explores the development of stereochemical analysis and its applications to the biosciences. Applications to pharmacology and therapeutics, food and beverage chemistry and the study of pesticides and other zenobiotics are also covered. The book looks into the molecular principles of chiral recognition and biological selectivity and discusses stereoselectivity in drug action and metabolism. Some of the specific issues covered include: gas and liquid chromatography of enantiomers on chiral stationary phases; stereochemical assays of chiral drugs; pyrethroid isomers; configurational modification of peptide hormones; chiral fruit flavours; and human pharmacokinetics of enantiomers administered as racemates.

目次

  • Partial table of contents:
  • ANALYTICAL AND BIOANALYTICAL ASPECTS
  • Gas Chromatography of Enantiomers on Chiral Stationary Phases (H. Frank)
  • Stereochemical Characterization of Drugs by Chiral Chromatography and Circular Dichroism (C. Bertucci, et al.)
  • BIOLOGICAL AND METABOLIC ASPECTS
  • Chiral Recognition in Insect Juvenile Hormone Metabolism (M. Peter)
  • Chiral Fruit Flavour Compounds: Stereodifferentiation and Fruit-Specific Distribution of Enantiomers (A. Mosandl, et al.)
  • Racemization of Wine Free Amino Acids as Function of Bottling Age (H. das Neves, et al.)
  • Catalytic Properties of Nonstereospecific Diisopropylfluorophosphatases (D. Lenz, et al.)
  • Stereoselective Aromatase Inhibition by the Enantiomers of 3-Cyclohexyl-3-(4-Aminophenyl)-2, 6-Piperidinedione (R. Hartman, et al.)
  • PHARMACOKINETIC AND PHARMACODYNAMIC ASPECTS
  • Stable Isotope Studies on the Stereochemistry of the Polymorphic Oxidation of Sparteine and Debrisoquine in Man (T. Ebner, et al.)
  • Stereospecific Analysis and Human Pharmacokinetics of the Enantiomers of Drugs Administered as Racemates (E. Mutschler, et al.)
  • Stereochemical Parameters of Importance for Dopamine D2-Receptor Activation (U. Hacksell, et al.)
  • Index.

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