Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies
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Bibliographic Information
Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies
（A Wiley-Interscience publication）
Wiley, c1991
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Contains selected papers from the Second International Conference on Alzheimer's Disease & Related Disorders held in Toronto, Canada, from July 15-20, 1990
Includes bibliographical references and index
Description and Table of Contents
Description
Alzheimers Disease: Basic Mechanisms, Diagnosis and Therapeutic Strategies Edited by Khalid Iqbal New York State Institute for Basic Research, New York, USA Donald R. C. McLachlan Centre for Research on Neurodegenerative Diseases, University of Toronto, Canada Bengt Winblad Department of Geriatric Medicine, Karolinska Institute, Stockholm, Sweden and Henry M. Wisniewski New York State Institute for Basic Research, New York, USA As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Although recognized as one of the most devastating diseases of the human brain, the etiology and pathogenesis of Alzheimers disease are still poorly understood. Continued research is required both into the basic mechanisms of the condition and into developing diagnostic and therapeutic strategies in the clinic. Presented here is a wide-ranging, authoritative and comprehensive coverage of the most recent and significant advances in basic research and clinical investigations of Alzheimers disease.
Areas represented include neuroimaging, brain energy metabolism, structural and molecular neuropathology, mechanisms of neuronal degeneration, role of brain amyloidosis, risk factors and epidemiology, environmental factors, genetic mechanisms, biomarkers, animal models and the clinical pharmacology of current and future therapeutic strategies. Contributions are drawn from the major research groups around the world, providing an invaluable information and reference source to both basic researchers and clinicians providing primary care for the unfortunate victims of Alzheimers disease. Titles of related interest from Wiley: Dahlem LS43: Etiology of Dementia of Alzheimers Type 0 471 92075 4 1988 Giaquinto: Aging and the Nervous System 0 471 91835 0 1988 Iqbal et al. : Alzheimers Disease and Related Disorders 0 471 56228 9 1989 Hindmarch, Hippius and Wilcock: Dementia: Molecules, Methods and Measures due Summer 1991
Table of Contents
Partial table of contents: CLINICAL COURSE. Multidisciplinary Validation of Two Dementia Categories (N. Verma, et al.). NEUROPATHOLOGY: STRUCTURAL AND BIOCHEMICAL. Entorhinal Lesions in Dementia (H. Braak & E. Braak). BRAIN AMYLOIDOSIS. Basement Membrane Heparan Sulphate Proteoglycan Is Part of Isolated Alzheimer's Amyloid Plaques (S. Narindrasorasak, et al.). ENVIRONMENTAL FACTORS. Aluminium in the Causation of Alzheimer's Disease: Population-Based Studies in England and Wales (C. Martyn & J. Candy). ANIMAL MODELS. Trisomy 16 Mouse Model of Alzheimer's Disease (A. Plioplys). BIOLOGICAL MARKERS/SYSTEMIC MARKERS. Brain Nicotinic Receptor Deficits in Alzheimer Patients as Studied by Positron Emission Tomography Technique (A. Nordberg, et al.). TREATMENT: CURRENT THERAPIES AND FUTURE DIRECTIONS/DRUG TRIALS. The Therapeutics of Alzheimer's Disease (K. Davis & V. Haroutunian). List of Contributors. Index.
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