Excitatory amino acid antagonists
著者
書誌事項
Excitatory amino acid antagonists
（Frontiers in pharmacology & therapeutics）
Blackwell Scientific Pub., 1991
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内容説明・目次
内容説明
Excitatory amino acids are normal components of the human brain which serve as transmitters of nerve impulses. Recent research has shown that during stroke, when the brain is starved of oxygen, they are released in very large quantities which causes calcium overload and leads to degeneration and death of nerve cells. Such damage gives rise to the paralysis and memory loss occurring after episodes of stroke. Newly developed antagonists to excitatory amino acids when given shortly after stroke are able to dramatically reduce the extent of the resulting neural damage. It is also likely that these drugs will be of significant benefit in the treatment of epilepsy as they attenuate the paroxysmal discharges of hyperexcitable neurones. Estimates of the potential market size for drugs active against neurological disorders have led to a major investment by the pharmaceutical industry in research directed to new antagonists of excitatory amino acids. This is, therefore, an appropriate moment to summarize what is known about these compounds and to try to assess their future prospects. This book gives a scholarly overview of the recent developments in this important field.
It is edited by the foremost authority on the subject and has been written by leading neuroscientists from all over the world, all of whom have made significant contributions to the subject. It is the first book in the world to be devoted specifically to excitatory amino acide antagonists and unlike most books in the field of neurochemistry, it is not based on a meeting! As such it will be of interest to all pharmacologists and neurologists engaged in research on the central nervous system and particularly those working on the
目次
- Historical introduction: key discoveries
- Excitatory amino acid neurotransmitters: anatomical systems
- Excitatory amino acid receptor subtypes
- Physiology and biophysics of the NMDA receptor channel complex
- Structure/activity relations of competitive NMDA receptor antagonists
- Non-competitive NMDA antagonists acting on the glycine site
- Non-competitive NMDA antagonists acting on the polyamine site
- Channel blocking drugs for the NMDA receptor
- Inhibitors of kainate and AMPA ionophore receptors
- The quisqualate metabotropic receptor: characterization and putative role
- Excitotoxicity
- Behavioural effects of NMDA antagonists
- Excitatory amino acid antagonists and therapy of epilepsy
- Excitatory amino acid antagonists: opportunities for the treatment of ischaemic brain damage in man
- Future prospects for excitatory amino acid antagonists
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