Manual of pharmacologic calculations with computer programs
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書誌事項
Manual of pharmacologic calculations with computer programs
Springer-Verlag, c1981
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book provides a collection of quantitative procedures in common use in we selected may be pharmacology and related disciplines. The procedures considered" core" since it is likely that all scientists who work with drugs will use these procedures at some time or another. By excluding very specialized topics, we managed to keep the size of the book small. thus making it handy reference-a handbook in the true sense. for quick Since many scientists and students now have access to electronic computers, of lower cost microcomputers is likely to increase com- and since the advent we also included a computer program for each puter availability even further, procedure. * The user need not know computer programming since all necessary information needed to run the programs is included here. The manual is divided into two parts. In the first, the pharmacologic basis for the calculation is briefly stated for each of the procedures (numbered 1 through 33). Then the appropriate equations (formulas) are given and an example of each calculation is provided. For each procedure, the discussion of theory and illustration of the calculation are brief and self-contained.
With the tables in the Appendix and a pocket calculator, all of the calculations can be done without reference to any other source. It is recommended that the pro- cedure and sample calculation be read and understood before going to the automated "magic" of the computer program in Part II.
目次
I: Computational Procedures.- 1. Dosage and Concentration: Drug Stock Solutions.- 2. Mean, Standard Deviation, and Confidence Limits.- 3. Linear Regression I.- 4. Linear Regression II: Lines through Origin.- 5. Analysis of the Regression Line.- 6. Parallel Lines I: Test for Parallelism.- 7. Parallel Lines II: Construction of Parallel Lines.- 8. Graded Dose-Response.- 9. Quantal Dose-Response: Probits.- 10. Relative Potency.- 11. Dissociation Constant I: Agonists.- 12. Dissociation Constant II: Partial Agonists.- 13. Dissociation Constant III: Perturbation Methods (Rate Constants in the Drug-Receptor Reaction).- 14. pA2 Analysis I: Schild Plot.- 15. pA2 Analysis II: Time-Dependent Method.- 16. pA2 Analysis III: Constrained Plot.- 17. Enzyme Kinetics I: Michaelis-Menten Equation.- 18. Enzyme Kinetics II: Competitive Inhibition.- 19. Enzyme Kinetics III: Noncompetitive Inhibition.- 20. First-Order Drug Decay.- 21. Scatchard Plot.- 22. Henderson-Hasselbach Equation.- 23. Exponential Growth and Decay.- 24. Constant Infusion with First-Order Elimination.- 25. Multiple Intravenous Injections.- 26. Area under a Curve: Simpson's Rule and Trapezoidal Rule.- 27. Analysis of Variance.- 28. t-Test I: Grouped Data.- 29. t-Test II: Paired Data.- 30. Chi-Square Test.- 31. Dunnett's Test (Comparison with a Control).- 32. Mann-Whitney Test.- 33. Method of Litchfield and Wilcoxon: Confidence Limits of ED50.- II: Computer Programs.- to Computer Programs.- S1 Dosage & Concentration: Drug Stock Solutions.- S2 Mean, Standard Deviation & Confidence Limits.- S3 Linear Regression I.- S4 Linear Regression II: Lines Through Origin.- S5 Analysis of the Regression Line.- S6 Parallel Lines I: Test for Parallelism.- S7 Parallel Lines II: Construction of Parallel Lines.- S8 Graded Dose-Response.- S9 Quantal Dose-Response: Probits.- S10 Relative Potency.- S11 Dissociation Constant I: Agonists.- S12 Dissociation Constant II: Partial Agonists.- S13 Dissociation Constant III: Perturbation Methods.- S14 pA2 Analysis I: Schild Plot.- S15 pA2 Analysis II: Time-Dependent Method.- S16 pA2 Analysis III: Constrained Plot.- S17 Enzyme Kinetics I: Michaelis-Menten Equation.- S18 Enzyme Kinetics II: Competitive Inhibition.- S19 Enzyme Kinetics III: Noncompetitive Inhibition.- S20 First-Order Drug Decay.- S21 Scatchard Plot.- S22 Henderson-Hasselbach Equation.- S23 Exponential Growth & Decay.- S24 Constant Infusion with First-Order Elimination.- S25 Multiple IV Injections.- S26 Area under a Curve: Trapezoidal & Simpson's Rules.- S27 Analysis of Variance.- S28 t-Test I: Grouped Data.- S29 t-Test II: Paired Data.- S30 Chi-Square Test.- S31 Dunnett's Test.- S32 Mann-Whitney U-Test.- S33 Litchfield & Wilcoxon Test.- Appendix: Mathematical Tables.
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