Negative schizophrenic symptoms : pathophysiology and clinical implications
Author(s)
Bibliographic Information
Negative schizophrenic symptoms : pathophysiology and clinical implications
（The Progress in psychiatry series / David Spiegel, series editor, no. 28）
American Psychiatric Press, c1991
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Note
Includes bibliographical references
Description and Table of Contents
Description
This book critically discusses the current status of negative schizophrenic symptoms with regard to their conceptualization, pathophysiology, etiology, and treatment. It discusses the validity of various competing concepts; reviews current biochemical, structural, and developmental theories to explain negative symptoms; outlines pharmacological and other treatment approaches; and delineates promising areas for future research. In the first section of the book, the concepts and clinical features of the negative-symptom syndrome are discussed, and the various rating instruments employed to measure this construct are critcally reviewed. In the next section, contributors review various biochemical hypotheses formulated to explain negative symptoms. Data implicating dopamine deficiency, cholinergic hyperfunction, and noradrenergic excess/deficiency in the production of negative symptoms are presented and neuro-endocrine abnormalities associated with negative symptoms are reviewed. Data on various structural abnormalities in schizophrenia as they pertain to the presence of the negative syndrome are reviewed.
In the final chapter, the authors inquire as to how the various concepts and pathophysiological theories of the negative-symptom construct might be integrated.
Table of Contents
Contributors. Foreword. Introduction. Concept and Phenomenology. The concept of the negative symptoms of schizophrenia. Longitudinal course of negative symptoms in schizophrenia. Negative sympomatology in schizophrenia: syndrome and subtype status. Negative symptom rating scales. Biochemical Hypotheses. Prefrontal dopamine and defect symptoms in schizophrenic symptoms. Noradrenergic mechanisms, state dependency, and negative symptoms in schizophrenia. Positive and negative symptoms and neuroendocrine dysfunction in schizophrenia. Structural and Developmental Theories. CT and MRI abnormalities in schizophrenia: relationship with negative symptoms. Current view of the type II syndrome: significance of age of onset, intellectual impairment, and structural changes in the brain. A developmental model of negative syndromes in schizophrenia. Genetic and environmental correlates of the positive and negative syndromes. Treatment. Therapeutic approaches to negative symptoms. Pharmacologic treatment of negative symptoms. Conclusion: is integration possible? References.
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