Central nervous system peptide mechanisms in stress and depression
著者
書誌事項
Central nervous system peptide mechanisms in stress and depression
(The Progress in psychiatry series / David Spiegel, series editor, no. 30)
American Psychiatric Press, c1991
1st ed
- alk. paper
大学図書館所蔵 全4件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references
内容説明・目次
内容説明
Over the past decade there has been a growth in the knowledge of the role of central peptidergic mechanisms in the patho-physiology of acute and chronic stress and affective illness. This book describes the research efforts of leading neuroscientists in this field, not only summarizing current knowledge, but also outlining future directions of research. In the first chapter, the authors provide a summary of current knowledge of the normal physiology of the limbic hypothalamic-pituitary-adrenal (LHPA)- axis. They also review studies delineating specific mechanisms in LHPA dysfunction in acute and chronic stress states and in affective illness. A creative series of animal studies in rats and rhesus monkeys defining the role of corticotropin-releasing factor in adaptive and maladaptive responses to acute and chronic stress is presented in chapter two. A summary of a number of studies that produce incontrovertible evidence for a mechanistic role of CRF in the patho-physiology of acute and chronic stress is given in the next section.
The fourth chapter reviews the results of a research strategy of using simultaneous assessments of CNS neurotransmitter activity and further emphasizes the complexity of these systems and their interrelationships. A review of the expanding literature on immune disturbances associated with acute and chronic stress and with depressive illnesses is presented in chapter five. The research reviewed in this volume summarizes new insights into the role of CNS peptidergic systems in normal adaptive response to stress and their potential dysfunction in maladaptive stress responses in human disease states. The contributors also point to future directions for both pre-clinical and clinical studies that hold the promise of specific pharmacotherapies directed at modulating and/or correcting neuropeptide dysfunctions that precipitates psychiatric illness.
目次
- Regulatory biology of the HPA-axis - an integrative approach, Juan F.Lopez et al
- animal studies implicating a role of corticotropin-releasing hormone in mediating behaviour associated with psychopathology, Ned H.Kalin and Lorey K.Takahashi
- corticotropin-releasing factor - brain and cerebrospinal fluid studies, M.Adriana Vargas, et al
- relationship between cerebrospinal fluid peptides and neurotransmitters in depression, S.Graig Risch et al
- cellular imune changes in stress and depression - role of corticotropin-releasing factor and endogenous opioid peptides, Michael Irwin.
「Nielsen BookData」 より