Mechanisms of lymphocyte activation and immune regulation III : developmental biology of lymphocytes
著者
書誌事項
Mechanisms of lymphocyte activation and immune regulation III : developmental biology of lymphocytes
（Advances in experimental medicine and biology, v. 292）
Plenum Press, c1991
- タイトル別名
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Mechanisms of lymphocyte activation and immune regulation 3
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注記
"Proceedings of the Third International Conference on Lymphocyte Activation and Immune Regulation, held February 16-18, 1990, in Newport Beach, California"--T.p. verso
Includes bibliographical references and index
内容説明・目次
内容説明
Recent advances in the understanding of the major events that shape the immune recog nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest."
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