- Volume
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pt. D ISBN 9780444815170
Description
This volume deals primarily with the chemistry of aliphatic acids bearing hydroxy, amino, and carbonyl groups (including a second carboxylic function). The authors were all asked to emphasise those areas which most closely reflect current trends in their respective subjects in addition to bringing the coverage up-to-date. One subject in particular, that of amino acid chemistry, has undergone a spectacular increase in activity in the last two decades, a fact associated with new methodology which allows the synthesis of biologically important polypeptides and advances in drug design which target smaller peptides and their mimics as control agents in many diseases. It was felt that this topic required an expansion to match the current interest. Therefore, Chapter 15 was divided into two subchapters so that protection methods for amino acids and coupling(' methods could be dealt with more fully. The chemistry of the nitrogen derivatives of the alkanes: nitroalkanes, nitronic acids, and related compounds is covered in Chapter 6. This chapter should have appeared 'n Volume IA/B, but was not completed on time.
The inclusion of this chapter completes that part of the Second Supplement which deals only with the acyclic aliphatic compounds.
- Volume
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pt. A and B ISBN 9780444881571
Description
In this first volume of the second supplements, progress between 1972 and 1990 in monofunctional aliphatic chemistry, excluding nitrogen compounds, is systematically reviewed and thoroughly referenced. The space devoted to individual topics follows current research and reflects activity in the area. Thus there is more emphasis on reagent chemistry and the control of stereochemistry in synthesis than in the first supplement. However, the reader will still find that less topical areas of chemistry are still painstakingly documented. In short, nothing of importance, or potential importance is omitted.
Table of Contents
1. The Saturated Hydrocarbons - Alkanes (D.F. Ewing). 2a. Acyclic Hydrocarbons: Alkenes (D.T. Hurst). 2b. Carbenes and Allenes (M. Sainsbury). 2c. Acyclic Hydrocarbons: Alkynes (A.M. Jones and S.P. Stanforth). 3a. Monohalogenoalkanes (R. Bolton). 3b. Polyhalogenoalkanes and Alkenyl Halides (R. Bolton). 4a. Monohydric Alcohols and Related Compounds (C.W. Thomas). 4b. Monohydric Alcohols and Related Compounds: Acyclic Ethers, Hydroperoxides, Peroxides and Esters of Inorganic Acids (C.W. Thomas). 5. Sulphur Analogues of the Alcohols and their Derivatives (D.W. Brown). 6. Nitrogen Derivatives of the Acyclic Hydrocarbons (This chapter will be included in a later sub-volume). 7a. Aliphatic Organometallic and Organometalloidal Compounds ( Derived from Metals of Groups, IA, IIA/B, IIIA, IVA, VA and VIA ) (A.J. Floyd). 7b. Aliphatic Organometallic and Organometalloid Compounds ( Compounds Derived from the Transition Metals ) (A.J. Floyd). Index.
- Volume
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pt. C ISBN 9780444897589
Description
In this second sub-volume the carbonyl compounds in their various forms are updated from 1972, a year before the first supplement was published. All salient new discoveries in this diverse subject area are included.
Table of Contents
8a. Aliphatic Carbonyl Compounds: Aliphatic Aldehydes (A. Furstner, H. Weidmann). Introduction. Syntheses with reduction of the number of carbon atoms. Synthesis with retention of the number of carbon atoms. Syntheses with extension by one carbon atom. Syntheses with extension by two carbon atoms. Syntheses with extension by three carbon atoms. Syntheses with extension by four or more carbon atoms. 8b. Aliphatic Ketones (D.J. Simmonds). Introduction. Saturated ketones. Unsaturated ketones. 9a. Monobasic Aliphatic Saturated Acids (J. Bergman). Introduction. Saturated monocarboxylic acids. Functional derivatives of carboxylic acids. Thiocarboxylic acids. Halogen substituted products of carboxylic acids. Ortho esters. 9b. Unsaturated Monobasic Acids (R.B. Miller). Introduction. Synthesis of unsaturated acids. Biological studies of unsaturated monobasic fatty acids. Individual unsaturated monobasic acids. 10. Carbon Monoxide and its Derivatives, Carbonic Acid and its Derivatives (I.G.C. Coutts). Reactions of carbon monoxide without transition-metal catalysis. Reactions of carbon monoxide with transition-metal catalysis. Metal carbonyls. Isocyanides, isonitriles. Carbonic acid and derivatives. Carbonic acid diesters, carbonates. Chloroformic esters (carbonochloridates). Carbonic acid halides. Sulphur analogues of carbonic acid derivatives. Dithiocarbonic O, S-acid, xanthic acid. Carbamic acid esters, carbamates. Orthocarbonic acid esters. 11. Carbamates and their allies (D.W. Anderson). Carbamates. Urea and its derivatives. Guanidine and its derivatives. Isocyanates and derivatives. Carbodiimide and its derivatives. Guide to the Index. Index.
- Volume
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pt. E, F, G ISBN 9780444898739
Description
Rodd's Chemistry of Carbon Compounds, Volume I: Aliphatic Compounds focuses on the chemistry of polyhydric alcohols and saccharides. The chemistry of polyhydric alcohols is a vast and crucially important area, not only because of the prominent roles that polyols have in their own right, but because of the way they and their modified forms are incorporated into natural products. The topics covered include the analogues, derivatives, and oxidation products of trihydric and tetrahydric alcohols; phospholipids; polyhydric alcohols and their oxidation products; synthesis, chemistry, structure and physical properties, and use in the synthesis as chiral templates and asymmetric synthesis of natural products of monosaccharides; and disaccharides and oligosaccharides. This text also discusses the applications of carbohydrates as chiral auxiliaries, templates, and starting materials in syntheses. This volume is a useful reference for students and organic chemists.
Table of Contents
Preface
List of Common Abbreviations and Symbols Used
Chapter 18. Trihydric Alcohols, Their Analogues and Derivatives and Their Oxidation Products: Trihydric Alcohols to Triketones
1. Preparation of Glycerol
2. Reactions of Glycerol
3. Use of Chiral Synthons Derived from Glycerol in Synthesis
(a) Chiral ?-Lactones
(b) The Synthesis Heteroyohimbine Alkaloid Precursors
4. Glycerides
Chapter 19. Trihydric Alcohols and Their Oxidation Products (Continued)
Dihydroxycarboxylic and Trihydroxycarboxylic Acids and Related Compounds
1. Dihydroxycarboxylic Acids
(I) Preparation of Mevalonic Acid and Mevalonolactone
(II) Biosynthesis of Isoleucine and Valine
2. Amino Hydroxy Carboxylic Acids
3. 2-Amino-2-Alkenoic Acids (Didehydroaminocarboxylic Acids)
4. Representative Amino Carboxylic Acids and Related Compounds
Chapter 20. Trihydric Alcohols and Their Oxidation Products (Continued)
Hydroxy- and Amino-Dicarboxylic Acids
Chapter 21. Phospholipids
General References
1. Synthesis of Phospholipids
(a) Halophosphate Reagents
(b) Cyclic Reagents
(c) The Cyclic Enediol Phosphoryl (CEP) Method
(d) Activating Reagents
(e) Oligonucleotide Methodology
(f) Glycidol Derivatives
(g) Semi-Synthetic Methods
2. Phospholipid Analogues
(a) Analogues Containing Sulphur
(b) Backbone Modifications
(c) Phosphonolipids
(d) Vesicles
(e) Membrane Probes
(f) Electron Transport
(g) Miscellaneous Analogues
3. Platelet-Activating Factor (PAF)
(a) Syntheses of PAF
(b) PAF Analogues
4. Phospholipase A2 Inhibitors
(a) Synthesis of PLA2 Inhibitors
Chapter 22. Polyhydric Alcohols and Their Oxidation Products
1. Introduction
2. Preparation and Synthesis of Alditols
(a) Reduction
(b) Electrolysis
(c) Enzymatic
(d) Syntheses
3. Conformation, Chelation and Chromatography
(a) Conformation and Stereochemistry
(b) Complexes and Chelation
(c) Chromatography
4. Reactions and Derivatives of the Alditols
(a) Use of Alditols in Asymmetric Synthesis
(b) Oxidation and Oxidation Products
(c) Cyclic Acetals
(d) Esters
(e) Ethers
5. Anhydroalditols
6. Deoxyalditols
7. Aminoalditols
8. Deoxynitroalditols
9. Sulphur Containing Derivatives
Chapter 23a. Monosaccharides: Synthesis, Chemistry, Structure and Physical Properties
1. Introduction
2. Synthesis of Monosaccharides
(a) Diels-Alder Types
(b) Oxirane Ring Openings
(c) Wittig Reactions
(d) Organometallic Reagents
(e) Miscellaneous Reactions
3. Amino Monosaccharides
(a) Oxirane Ring Opening
(b) Condensation Type Reaction
(c) Diels-Alder Type Constructions
(d) Miscellaneous Reactions
4. Monosaccharides Having a Phosphorus Atom in the Ring
5. Cyano Monosaccharides
6. Halides of Monosaccharides
7. Thio and Thia Monosaccharides
8. Carbocyclic Analogues of Monosaccharides
9. Chemistry of Monosaccharides
10. Structure and Physical Properties of Monosaccharides
Chapter 23b. Monosaccharides: Use in Synthesis as Chiral Templates
Introduction
1. Asymmetric Reduction
(a) Asymmetric Homogeneous Hydrogenation with Transition Metal Complexes of Monosaccharide Phosphines
(b) Asymmetric Heterogeneous Hydrogenation
(c) Asymmetric Hydrosilylation
(d) Chiral Reducing Agents Derived from Monosaccharides
2. Enantioselective Alkylation Reactions
(a) Monosaccharide Derived Enolates in Enantioselective Aldol Reactions
(b) Enantioselective Alkylation of Monosaccharide Derived Carbanions
(c) Enantioselective Alkylation with Monosaccharide Electrophiles
3. Monosaccharides as Chiral Auxiliaries for Cycloaddition Reactions
(a) Asymmetric Diels-Alder Reactions
(b) Asymmetric [3 + 2] Cycloaddition Reactions with Monosaccharide Auxiliaries
(c) Asymmetric [2 + 2] Cycloadditions with Monosaccharide Auxiliaries
4. Asymmetric Carbenoid Additions with Monosaccharide Bearing Copper Catalysts
Chapter 23c. Monosaccharides: Use in the Asymmetric Synthesis of Natural Products
Introduction
1. Use of Monosaccharides for the Assembly of Natural Products With Carbocyclic Ring Systems
(a) Radical Cyclisation Strategies
(b) Cycloaddition Strategies
(c) Nucleophilic Cyclisation Strategies for the Synthesis of Carbocyclic Ring Systems in Natural Products
(d) Cationic Cyclisation Strategies
2. Use of Monosaccharides for the Assembly of Molecules with Heterocyclic Rings
3. Use of Monosaccharides in the Total Synthesis of Naturally-Occurring Macrolides
Chapter 24. Disaccharides and Oligosaccharides
Introduction
1. Di- and Oligosaccharides
(a) Synthesis
(b) Physical Methods
2. Disaccharides and Related Compounds
(a) Tetrosylhexoses
(b) Pentosylpentoses
(c) Pentosylhexoses, Hexosylpentoses
(d) Deoxyhexosylpentoses
(e) Deoxyhexosyldeoxyhexoses
(f) Deoxyhexosylhexoses
(g) Hexosyldeoxyhexoses
(h) Hexosylhexoses
(i) KDO-Containing Disaccharides
(j) Non-Reducing Disaccharides
(k) Nitrogen-Containing Disaccharides
(l) Uronic Acids
3. Trisaccharides and Related Compounds
(a) Neutral Sugar Containing Trisaccharides
(b) Deoxysugar-Containing Trisaccharides
(c) Nitrogen-Containing Trisaccharides
4. Tetrasaccharides and Higher Oligosaccharides
5. Sulphur-Containing Oligosaccharides
Chapter 25. Tetrahydric Alcohols, Their Analogues, Derivatives and Oxidation Products
1. Tetrahydric Alcohols
(a) Tetritols
(b) Derivatives of The Tetritols
(c) Homologous Tetrahydric Alcohols
2. Trihydroxyaldehydes and Trihydroxyketones
3. Dihydroxydiones and Their Derivatives
4. Trihydroxycarboxylic Acids
5. Dihydroxyalkanedicarboxylic Acids
6. Dioxodicarboxylic Acids
7. Tetracarboxylic Acids
(a) Alkanetetracarboxylic Acids
(b) Alkenetetracarboxylic Acids
Guide to the Index
Index
by "Nielsen BookData"
