Pharmacokinetics for anaesthesia

著者

書誌事項

Pharmacokinetics for anaesthesia

C.J. Hull

Butterworth-Heinemann, c1991

大学図書館所蔵 件 / 全8件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Professor Christopher Hull has brought together in one text, the information and support systems for the clinician's clear understanding of the value of pharmacokinetics to the anaethetic care of patients. This book ranges far and wide over the areas necessary for an understanding of those activities in which the body deals with anaesthetic drugs to it. There are splendid summary chapters on the basic mathematics (made reasonably comprehensive for the novice) and the underlying physical chemistry of the methods by which administered drugs gain access to their target cells and tissues in the body to produce appropriate and desirable actions. The author leads the reader into application of these fundamental scientific concepts to the behaviour of actual drugs that the anaesthetist uses in his practice to provide a more rational understanding of how they behave and, therefore, to help the reader to master their admistration for increased patient safety as well as for clinical effectiveness. Professor Hull concludes his computer treatise on pharmacokinetic activity.

目次

  • Part 1 Basic essentials: a mathematical toolbox
  • molecules in action
  • passage of drugs across membranes
  • some basic pharmacokinetic concepts. Part 2 What happens to drugs in the body: drug uptake and availability
  • drug distribution
  • the dynamic of drug action
  • metabolism and excretion of drugs
  • variation in drug disposition II - pregnancy, disease, drugs and anaesthetesia. Part 3 Pharmacokinetic analysis: the measurement of drug concentrations in body fluids
  • the one compartment open model
  • models with more than one compartment
  • the identification of compartmental models
  • physiological models
  • some more advanced ideas. Part 4 Pharmacokinetics of some drugs used in anaesthesia: inhalational anaesthetic agents
  • intravenous anaesthetic agents
  • opioids
  • neuromuscular blocking agents. Part 5 Putting pharmacokinetics to work: a toolbox for compartmental models
  • dosing strategies and control. Appendices: estimation of the area under a concentration-time curve
  • computer program - PROJECT.

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